175 -2 (88) 2026 - Axmadjonova G.M., Asrankulova S.K. - MORPHO-HISTOPATHOLOGICAL AND MOLECULAR GENETIC CORRELATIONS IN EARLY REPRODUCTIVE LOSSES

MORPHO-HISTOPATHOLOGICAL AND MOLECULAR GENETIC CORRELATIONS IN EARLY REPRODUCTIVE LOSSES

Axmadjonova G.M. - Andijan State Medical Institute

Asrankulova S.K. - Andijan State Medical Institute

Resume

The aim of this study was a comprehensive morphological and molecular genetic analysis of aborted material from the first trimester of pregnancy to assess the contribution of PPARGC1A (Gly482Ser), MTHFR (A1298C), and F2 (20210G/A) polymorphisms to the development of pathological changes in the chorion and decidual tissue. Macro- and microscopic evaluation of the samples was performed, followed by a comparative interpretation of histological features and genetic markers. It was found that the morphological pattern of maternal perfusion insufficiency and impaired trophoblastic invasion were statistically more frequently associated with thrombophilic gene variants. A comprehensive assessment allowed for a definitive diagnostic conclusion in 96% of cases.

Keywords: early pregnancy loss, villous chorion, trophoblast, thrombophilia, PPARGC1A, MTHFR, F2.

First page

947

Last page

952

For citation:Axmadjonova G.M., Asrankulova S.K. - MORPHO-HISTOPATHOLOGICAL AND MOLECULAR GENETIC CORRELATIONS IN EARLY REPRODUCTIVE LOSSES//New Day in Medicine 2(88)2026 947-952 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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