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  • 34 -3 (89) 2026 - Mun A.V., Utemuratova D.M. - MODERN CONCEPTS OF THE EPIDEMIOLOGY AND PATHOGENESIS OF URTICARIA: A PERSPECTIVE BASED ON INTERNATIONAL GUIDELINES AND POPULATION STUDIES

34 -3 (89) 2026 - Mun A.V., Utemuratova D.M. - MODERN CONCEPTS OF THE EPIDEMIOLOGY AND PATHOGENESIS OF URTICARIA: A PERSPECTIVE BASED ON INTERNATIONAL GUIDELINES AND POPULATION STUDIES

MODERN CONCEPTS OF THE EPIDEMIOLOGY AND PATHOGENESIS OF URTICARIA: A PERSPECTIVE BASED ON INTERNATIONAL GUIDELINES AND POPULATION STUDIES

Mun A.V. - Tashkent State Medical University

Utemuratova D.M. - Tashkent State Medical University

Resume

Urticaria is a common mast cell–mediated disease of the skin and mucous membranes, characterized by sudden wheals, angioedema, or their combination. The GA²LEN/EAACI/EuroGuiDerm/APAAACI 2026 consensus distinguishes acute (6 weeks) forms; chronic urticaria is further divided into spontaneous (CSU) and inducible (CIndU) types. CSU occurs more frequently in women, in young and middle-aged individuals, and in countries with lower average income. Population studies (China ≈ 41,000, USA) report a lifetime prevalence of 7–15% and point prevalence of 0.5–1%. Pathogenesis involves mast cell and basophil activation through IgE-dependent (autoallergy) and IgG-dependent (type IIb) mechanisms, as well as contributions from the microbiota, low-grade inflammation, and stress factors. This review summarizes data from 2021–2026, highlighting trends, gaps, and clinical implications.

Keywords: urticaria, epidemiology, pathogenesis, international guidelines.

First page

209

Last page

214

For citation:Mun A.V., Utemuratova D.M. - MODERN CONCEPTS OF THE EPIDEMIOLOGY AND PATHOGENESIS OF URTICARIA: A PERSPECTIVE BASED ON INTERNATIONAL GUIDELINES AND POPULATION STUDIES//New Day in Medicine 3(89)2026 209-214 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

List of References

  1. He L, Yi W, Huang X, Long H, Lu Q. Chronic urticaria: advances in understanding of the disease and clinical management. Clin Rev Allergy Immunol. 2021;61(3):424–448. doi:10.1007/s12016-021-08886-x. Bronckers IMGJ, Paller AS, West DP, et al. A comparison of psoriasis severity in pediatric patients treated with methotrexate vs biologic agents. JAMA Dermatol. 2020;156(4):384-392. doi:10.1001/ jamadermatol.2019.4835
  2. Küçük ÖS, Yücel MB. Clinical and molecular aspects of managing chronic spontaneous urticaria: identifying endotypes, phenotypes, and determinants of treatment response and resistance. Front Allergy. 2025;6:1706705. doi:10.3389/falgy.2025.1706705.
  3. Li J, Mao D, Liu S, et al. Epidemiology of urticaria in China: a population-based study. Chin Med J (Engl). 2022;135(11). doi:10.1097/CM9.0000000000002172.
  4. Liu Xiaoli, Yuan Cao, Wenhui Wang. Burden of and trends in urticaria globally, regionally, and nationally from 1990 to 2019: systematic analysis. JMIR Public Health Surveill. 2023;9:e50114. doi:10.2196/50114.
  5. Mauren M, et al. The classification, pathogenesis, diagnostic workup, and management of urticaria: an update. J Allergy Clin Immunol Pract. 2021;9(11):e pub ahead of print. doi:10.1007/164_2021_506
  6. Peck G, et al. Global epidemiology of urticaria: increasing burden among children, females and low-income regions. Acta Derm Venereol. 2021;101:adv00433. doi: 10.2340/00015555-3796.
  7. Sanchez-Borges M, Ansotegui IJ, Baiardini I, et al. The challenges of chronic urticaria part 1: epidemiology, immunopathogenesis, comorbidities, quality of life, and management. World Allergy Organ J. 2021;14(6):100533. doi:10.1016/j.waojou.2021.100533.
  8. Soong W, Patil D, Rodrigues J, et al. Clinical profile, prevalence, and burden of chronic spontaneous urticaria in the United States. World Allergy Organ J. 2025;18(8):101081. doi:10.1016/j.waojou.2025.101081.
  9. Tan S, Chen Z, Lin T. Global, regional, and national burden of urticaria (1990–2021), its potential risk factors, and projections to 2046. BMC Public Health. 2025;25:2709doi:10.1186/s12889-025-23321-y
  10. Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(3):734–766. doi:10.1111/all.15090.
  11. Zuberbier T, Metz M, Giménez-Arnau A, et al. The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. Allergy. 2026. doi: 10.1111/all.70210.

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