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  • 21 -9 (95) 2026 - G’ulomova Sh.Q. - POSTMENOPAUZADAGI AYOLLARDA FGF-23/α-KLOTHO TIZIMI, MINERAL ALMASHINUVI BIOMARKERLARI VA SUYAK MINERAL ZICHLIGI O’RTASIDAGI O’ZARO BOG’LIQLIKNI KOMPLEKS TAHLILIY BAHOLASH

21 -9 (95) 2026 - G’ulomova Sh.Q. - POSTMENOPAUZADAGI AYOLLARDA FGF-23/α-KLOTHO TIZIMI, MINERAL ALMASHINUVI BIOMARKERLARI VA SUYAK MINERAL ZICHLIGI O’RTASIDAGI O’ZARO BOG’LIQLIKNI KOMPLEKS TAHLILIY BAHOLASH

POSTMENOPAUZADAGI AYOLLARDA FGF-23/α-KLOTHO TIZIMI, MINERAL ALMASHINUVI BIOMARKERLARI VA SUYAK MINERAL ZICHLIGI O’RTASIDAGI O’ZARO BOG’LIQLIKNI KOMPLEKS TAHLILIY BAHOLASH

G’ulomova Sh.Q. - Abu Ali ibn Sino nomidagi Buxoro davlat tibbiyot instituti

Rezyume

Postmenopauzal osteoporoz suyak mineral zichligining (BMD) progressiv kamayishi va sinishlar xavfining ortishi bilan tavsiflanadigan muhim metabolik suyak kasalligidir. Estrogen yetishmovchiligi postmenopauzadagi suyak yo’qotilishining asosiy omili hisoblanishiga qaramay, mineral almashinuvining tizimli regulyatorlari ham skelet holatiga ta’sir ko‘rsatishi mumkinligi haqida dalillar tobora ko‘paymoqda. Fibroblast o’sish omili 23 (FGF-23) va α-Klotho fosfat gomeostazi, D vitamini metabolizmi hamda suyak-mineral almashinuvini boshqarishda ishtirok etuvchi muhim endokrin signal tizimini tashkil etadi. Asosan osteotsitlar va osteoblastlar qatoriga mansub hujayralar tomonidan ishlab chiqariladigan FGF-23 buyrakda fosfatning qayta so’rilishini kamaytiradi va 1,25-digidroksivitamin D ishlab chiqarilishini bostiradi. α-Klotho, ayniqsa buyrakda, klassik FGF-23 signalizatsiyasi uchun muhim koreseptor vazifasini bajaradi. FGF-23, α-Klotho, paratireoid gormoni (PTH), kalsiy, fosfat va D vitamini o’rtasidagi o‘zaro ta’sir alohida gormonal yo‘ldan ko‘ra murakkab boshqaruv tarmog‘ini hosil qiladi. Postmenopauzadagi ayollarda FGF-23, α-Klotho va BMD o‘rtasidagi bog’liqlikni o‘rgangan mavjud tadqiqotlarda turlicha natijalar olingan. Ayrim tadqiqotlarda osteoporozli ayollarda FGF-23 konsentratsiyasi yuqoriroq bo’lgani qayd etilgan bo‘lsa, boshqalarida FGF-23 va BMD o‘rtasida mustaqil bog‘liqlik aniqlanmagan. Aksincha, bir qator tadqiqotlar qonda α-Klotho konsentratsiyasi yuqoriroq bo‘’lishi BMD kattaroq bo‘lishi va osteoporoz ehtimolining pastligi bilan bog‘liq bo‘lishi mumkinligini ko‘rsatadi. Ushbu tafovutlar buyrak funksiyasi, yosh, D vitamini holati, tahlil usuli, menopauza davomiyligi, tana tarkibi va boshqa konfaunder omillardagi farqlar bilan izohlanishi mumkin. Ushbu sharh postmenopauzadagi ayollarda FGF-23/α-Klotho tizimi, mineral almashinuvi biomarkerlari va BMD bo’yicha mavjud dalillarni umumlashtiradi hamda kelgusidagi klinik tadqiqotlar uchun kompleks biomarker va statistik yondashuvni taklif etadi.

Kalit so‘zlar: FGF-23; α-Klotho; postmenopauzadagi ayollar; osteoporoz; suyak mineral zichligi; kalsiy; fosfat; D vitamini; PTH; mineral almashinuvi.

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For citation:G’ulomova Sh.Q. - POSTMENOPAUZADAGI AYOLLARDA FGF-23/α-KLOTHO TIZIMI, MINERAL ALMASHINUVI BIOMARKERLARI VA SUYAK MINERAL ZICHLIGI O’RTASIDAGI O’ZARO BOG’LIQLIKNI KOMPLEKS TAHLILIY BAHOLASH//New Day in Medicine 9(95)2026 159-168 https://newdayworldmedicine.com/en/new_day_medicine/9-95-2026

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