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  • 26 -9 (95) 2026 - Erimbetova D.T., Adilbekova D.B., Ahrorov Abdulaziz A., Toshpulatov S.S. - ONALARDAGI QANDLI DIABET XASTALIGI SHAROITIDA TUG’ILGAN AVLODNING REPRODUKTIV TIZIMI A’ZOLARIDAGI MORFOFUNKSIONAL O’ZGARISHLAR

26 -9 (95) 2026 - Erimbetova D.T., Adilbekova D.B., Ahrorov Abdulaziz A., Toshpulatov S.S. - ONALARDAGI QANDLI DIABET XASTALIGI SHAROITIDA TUG’ILGAN AVLODNING REPRODUKTIV TIZIMI A’ZOLARIDAGI MORFOFUNKSIONAL O’ZGARISHLAR

ONALARDAGI QANDLI DIABET XASTALIGI SHAROITIDA TUG’ILGAN AVLODNING REPRODUKTIV TIZIMI A’ZOLARIDAGI MORFOFUNKSIONAL O’ZGARISHLAR

Erimbetova D.T., Adilbekova D.B., Ahrorov Abdulaziz A., Toshpulatov S.S. - Toshkent Davlat Tibbiyot Universiteti

Rezyume

Qandli diabet — homiladorlik davrida ona organizmida yuzaga keladigan eng keng tarqalgan metabolik asoratlardan biri bo’lib, u nafaqat ona salomatligiga, balki rivojlanayotgan homilaning barcha organ va tizimlariga, jumladan reproduktiv tizimga ham chuqur ta’sir ko’rsatadi. So’nggi yillarda olib borilgan eksperimental va klinik tadqiqotlar shuni ko’rsatmoqdaki, onadagi surunkali giperglikemiya “fetal dasturlash” mexanizmi orqali qiz avlodning bachadoni, bachadon naylari va tuxumdonlarida chuqur morfologik va funksional o’zgarishlarni keltirib chiqaradi. Ushbu maqolada oxi4gi yillarda olib borilgan ilmiy-tadqiqot ishlari chuqur tizimli hamda taqqoslama tahlil qilinib, qandli diabetli onalardan tug’ilgan avlodning ichki jinsiy a’zolaridagi struktur va funksional buzilishlari tizimli tarzda yoritildi. Tahlil natijalari shuni ko’rsatdiki, bachadon endometriysi va miometriysida atrofik va yallig’lanish xarakteridagi o’zgarishlar, bachadon naylarida silliq mushak va epiteliy funksiyasining buzilishi, tuxumdonlarda esa follikulogenez jarayonining susayishi, oositlarda mitoxondrial disfunksiya va oksidativ stressning kuchayishi kuzatiladi. Bundan tashqari, epigenetik o’zgarishlar (DNK metilatsiyasi, gistonlarning modifikatsiyasi) orqali bu buzilishlarning keyingi avlodlarga ham uzatilishi mumkinligi haqida dalillar keltirilgan. Maqola turli tadqiqot modellarini solishtirma tahlil qilish orqali muammoning ko’p qirrali genezini ochib beradi.

Kalit so’zlar: qandli diabet, gestatsion diabet, fetal dasturlash, bachadon, bachadon naylari, tuxumdon, follikulogenez, oksidlanish stressi, epigenetika, reproduktiv tizim, avlod salomatligi.

First page

189

Last page

198

For citation:Erimbetova D.T., Adilbekova D.B., Ahrorov Abdulaziz A., Toshpulatov S.S. - ONALARDAGI QANDLI DIABET XASTALIGI SHAROITIDA TUG’ILGAN AVLODNING REPRODUKTIV TIZIMI A’ZOLARIDAGI MORFOFUNKSIONAL O’ZGARISHLAR//New Day in Medicine 9(95)2026 189-198 https://newdayworldmedicine.com/en/new_day_medicine/9-95-2026

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