• Home
  • NEW DAY MEDICINE
  • 11 (49) 2022
  • 83 -11 (49) 2022 — Nurbayev F.E., Raupov A.O., — LIVER DAMAGE IN COVID-19: ETIOLOGY, CLINIC, PROGNOSIS, TREATMENT AND PREVENTION

83 -11 (49) 2022 — Nurbayev F.E., Raupov A.O., — LIVER DAMAGE IN COVID-19: ETIOLOGY, CLINIC, PROGNOSIS, TREATMENT AND PREVENTION

LIVER DAMAGE IN COVID-19: ETIOLOGY, CLINIC, PROGNOSIS, TREATMENT AND PREVENTION

Nurbayev F.E., Bukhara State Medical Institute. Uzbekistan

Raupov A.O., Bukhara State Medical Institute. Uzbekistan

Sharipova N.Q., Bukhara State Medical Institute. Uzbekistan

Djumayev X. Bukhara State Medical Institute. Uzbekistan

Resume

This article is devoted to the analysis of available data on etiological factors, clinical features, disease prognosis, treatment methods and measures to prevent liver damage in a new coronavirus infection.

Given that liver injury is one of the most common extrapulmonary manifestations of SARS-CoV-2 infection, this article reviews several factors currently affecting the liver in COVID-19: viral immunologic injury, hypoxia, systemic inflammation , data on drug toxicity were analyzed.
This article analyzes information about liver dysfunction in Covid-19, its characteristics, disease prognosis, treatment tactics and preventive measures.

Keywords: COVID-19, ALT, AST, LDG, alkaline phosphatase.

First page

475

Last page

481

For citation: Nurbayev F.E., Raupov A.O., Sharipova N.Q., Djumayev X. LIVER DAMAGE IN COVID-19: ETIOLOGY, CLINIC, PROGNOSIS, TREATMENT AND PREVENTION //New Day in Medicine 11(49)2022 475-481 https://clck.ru/32segs

LIST OF REFERENCES:

  1. Драпкина О.М., Маев И.В., Бакулин И.Г. и др. / Drapkina O.M., Maev I.V., Bakulin I.G. et al. Временные методические рекомендации: «Болезни органов пищеварения в условиях пандемии новой коронавирусной инфекции (COVID-19)» /Vremenny`e metodicheskie
    rekomendacii: «Bolezni organov pishhevareniya v usloviyax pandemii novoj koronavirusnoj infekcii (COVID-19)» [Interim guidelines: «Diseases of the digestive system in the context
    of the novel coronavirus infection (COVID-19) pandemic»] // Профилактическая медицина / Profilakticheskaya medicina [Тhe Russian Journal оf Preventive Medicine]. – 2020. – Т. 23,
    № 3. – С. 2120–2152. – doi:10.17116/profmed202023032120. (In Russ.; abstr. in Engl.).
  2. Falcao M.B., de Goes Cavalcanti L.P., Filho N.M. F., Antunes de Brito C.A. Case report: hepatotoxicity associated with the use of hydroxychloroquine in a patient with novel coronavirus disease (COVID-19) // Am. J. Trop. Med. Hyg. – 2020. – No. 102 (6). – Р. 1214–1216. – doi:10.4269/ajtmh.20-0276.
  3. В.И. Петров, А.В. Пономарева, И.В. Ивахненко, О.В. Разваляева, Б.А. Мешрки, В.И. Стаценко. Этиопатогенетические аспекты повреждения печени у пациентов с COVID-19 // Вестник ВолгГМУ –Выпуск 4 (76 ). 2020 . С. 11- УДК 616-06
  4. COVID-19 and the liver D. Jothimani, R. Venugopal, M. F. Abedin, I. Kaliamoorthy, M. Rela. J Hepatol. 2020 Jun 15. doi: 10.1016/j.jhep.2020.06.006 [Epub ahead of print] PMCID: PMC7295524 PMID: 3255366
  5. Mehta P., McAuley D.F., Brown M., et al. HLH Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression // Lancet. – 2020. – No. 395. – Р.1033–1034. – doi:10.1016/s0140-6736(20)30628-0.
  6. Adams D.H., Hubscher S.G. Systemic viral infections and collateral damagein the liver //Am J Pathol. – 2006. – No. 168 (4). – Р.1057–1059. – doi:10.2353/ajpath.2006.051296.
  7. Yeo C., Kaushal S., Yeo D. Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? //Lancet Gastroenterol Hepatol. – 2020. – No. 5. – Р.335–337. – doi:10.1016/S2468-1253(20)30048-0.
  8. Гриневич В. Б., Кравчук Ю. А., Педь В. И. и др. / Grinevich V. B., Kravchuk Yu. A., Ped V. I., et al. Ведение пациентов с заболеваниями органов пищеварения
    в период пандемии COVID-19. Клинические рекомендации Научного общества гастроэнтерологов России / Vedenie pacientov s zabolevaniyami organov pishhevareniya
    v period pandemii COVID-19. Klinicheskie rekomendacii Nauchnogo obshhestva gastroe`nterologov Rossii [Management of patients with digestive diseases during
    the COVID-19 pandemic: Clinical Practice Guidelines by the Gastroenterological Scientifi c Society of Russia] // Экспериментальная и клиническая гастроэнтерология /
    E`ksperimental`naya i klinicheskaya gastroe`nterologiya [Experimental and Clinical Gastroenterology]. – 2020. – № 179 (7). – С. 4–51. – doi:10.31146/1682-8658-ecg-179-
    7-4-51. (In Russ.; abstr. in Engl.).
  9. Bangash M. N.; Patel J.; Parekh D. COVID-19 and the liver: Little cause for concern. Lancet
    Gastroenterol. Hepatol. 2020, 5, 529–530. DOI: 10.1016/S2468–1253(20)30084–4.
  10. Cui Y, Tian M, Huang D, Wang X, Huang Y, et al. A 55-Day-Old Female Infant Infected With 2019 Novel Coronavirus Disease: Presenting With Pneumonia, Liver Injury, and Heart Damage. //J Infect Dis. 2020 May 11; 221 (11): 1775–1781. DOI: 10.1093/infdis/jiaa113.
  11. Ивашкин В.Т., Шептулин А.А., Зольникова О.Ю. и др. / Ivashkin V.T., Sheptulin A.A., Zol`nikova O.Yu., et al. Новая коронавирусная инфекция (COVID-19) и система органов пищеварения /Novaya koronavirusnaya infekciya (COVID-19) i sistema organov pishhevareniya [New Coronavirus Infection (COVID-19) and Digestive System] // Российский журнал гастроэнтерологии, гепатологии, колопроктологии / Rossijskij zhurnal gastroe`nterologii, gepatologii, koloproktologii [Russian Journal of Gastroenterology,
    Hepatology, Coloproctology]. – 2020. – № 30 (3). – С.7–13. – URL: https://doi.org/10.22416/1382-4376-2020-30-3-7. (In Russ.; abstr. in Engl.).
  12. Guan W.J., Ni Z.Y., Hu Y., et al. China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China //NEngl J Med. – 2020. –
    No. 382. – Р. 1708–1720. – doi: 10.1056/NEJMoa2002032
  13. Hu L.L., Wang W.J., Zhu Q.J., Yang L. Novel coronavirus pneumonia-related liver injury: etiological analysis and treatment strategy //Zhonghua Gan Zang Bing Za Zhi. – 2020. – No. 28. – Р. 97–99. – doi: 10.3760/cma.j.issn.1007-3418.2020.02.001
  14. Xie H., Zhao J., Lian N., et al. Clinical characteristics of non-ICU hospitalized patients withcoronavirus disease 2019 and liver injury: A retrospective study // Liver Int. – 2020. – No. 40. – Р. 1321–1326. – doi: 10.1111/liv.14449.
  15. Wu J, Song S, Cao HC, Li LJ. Liver diseases in COVID-19: Etiology, treatment and prognosis. World J Gastroenterol. 2020; 26 (19): 2286–2293. DOI: 10.3748/wjg.v26.i19.2286.
  16. Ronco C., Navalesi P., Vincent J.L. Coronavirus epidemic: preparing for extracorporeal organ support in intensive care // Lancet Respir Med. – 2020. – No. 8. – Р. 240–241. – doi:10.1016/S2213-2600(20)30060-6.
  17. Day M. Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists // BMJ. – 2020. – No. 368. – Р. 1086. – doi: 10.1136/bmj.m1086.
  18. Schultz F., Hasan A., Alvarez-Laviada A., et al. The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac
    fibroblasts // Prog Biophys Mol Biol. – 2016. – No. 120 (1-3). – Р.149–163. – doi: 10.1016/j.pbiomolbio.2016.01.003.
  19. В.И. Петров, А.В. Пономарева, И.В. Ивахненко, О.В. Разваляева, Б.А. Мешрки, В.И. Стаценко. Этиопатогенетические аспекты повреждения печени у пациентов С COVID-19 // Вестник ВолгГМУ –Выпуск 4(76). 2020. С. 13- УДК 616-06

file

download