26 -12 (62) 2023 — Makhmudova L.I., Abdullayev I.A. — GUT-BRAIN AXIS IN THE PATHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME

GUT-BRAIN AXIS IN THE PATHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME

Makhmudova L.I. Bukhara State Medical Institute named after Abu Ali ibn Sina

Abdullayev I.A. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The literature review is devoted to the study of factors that occupy an important place in the pathophysiology of irritable bowel syndrome, such as the relationship between the central and enteral nervous system, intestinal barrier function, gene polymorphism, low-level inflammation, imbalance of neurotransmitters and cytokines, as well as changes in the intestinal microbiome.

Keywords: irritable bowel syndrome, genes, inflammation, cytokines, microbiome, psychosomatics

First page

136

Last page

142

For citation: Makhmudova L.I., Abdullayev I.A. – GUT-BRAIN AXIS IN THE PATHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME //New Day in Medicine 2023 12(62): 136-142 https://newdaymedicine.com/index.php/2023/12/13/l-580/

LIST OF REFERENCES:

  1. Drossman DA. Functional gastrointestinal disorders: what’s new for Rome IV? // Lancet Gastroenterol Hepatol 2016;1:6-8.
  2. Tang HY, Jiang AJ, Wang XY, Wang H, Guan YY, Li F, Shen GM. Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review. // Ann Transl Med 2021;9(14):1187.
  3. Soares RL. Irritable bowel syndrome: a clinical review. // World J Gastroenterol 2014;20:12144-60.
  4. Mearin F, Lacy BE, Chang L, et al. Bowel disorders. Gastroenterology 2016. // Epub ahead of print. doi: 10.1053/j.gastro.2016.02.031.
  5. Boyce PM, Talley NJ, Burke C, et al. Epidemiology of the functional gastrointestinal disorders diagnosed according to Rome II criteria: an Australian population-based study. // Intern Med J 2006;36:28-36.
  6. Sperber AD, Bangdiwala SI, Drossman DA, et al. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study. // Gastroenterology 2021;160:99-114.e3.
  7. Houghton LA, Heitkemper M, Crowell M, et al. Age, gender and women’s health and the patient. Gastroenterology 2016. // Epub ahead of print. doi: 10.1053/j.gastro.2016.02.017.
  8. Bellini M, Gambaccini D, Stasi C, et al. Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy. // World J Gastroenterol 2014;20:8807-20.
  9. Talley NJ, Holtmann G, Walker MM. Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology. // J Gastroenterol 2015;50:601-13.
  10. D’Amato M. Genes and functional GI disorders: from casual to causal relationship. // Neurogastroenterol Motil 2013;25:638-49.
  11. Gazouli M, Wouters MM, Kapur-Pojskić L, et al. Lessons learned-resolving the enigma of genetic factors in IBS. // Nat Rev Gastroenterol Hepatol 2016;13:77-87.
  12. Beyder A, Mazzone A, Strege PR, et al. Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome. // Gastroenterology 2014;146:1659-68.
  13. Grasberger H, Chang L, Shih W, et al. Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. // Am J Gastroenterol 2013;108:1766-74.
  14. Wouters MM, Lambrechts D, Knapp M, et al. Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome. // Gut 2014;63:1103-11.
  15. Camilleri M, Kolar GJ, Vazquez-Roque MI, et al. Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits. // Am J Physiol Gastrointest Liver Physiol 2013;304:G553-60.
  16. Ek WE, Reznichenko A, Ripke S, et al. Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. // Gut 2015;64:1774-82.
  17. Czogalla B, Schmitteckert S, Houghton LA, et al. A meta-analysis of immunogenetic Case-Control Association Studies in irritable bowel syndrome. // Neurogastroenterol Motil 2015;27:717-27.
  18. Swan C, Duroudier NP, Campbell E, et al. Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. // Gut 2013;62:985-94.
  19. Kadiyska T, Tourtourikov I, Popmihaylova AM, et al. Role of TNFSF15 in the intestinal inflammatory response. // World J Gastrointest Pathophysiol 2018;9:73-8.
  20. Mahurkar S, Polytarchou C, Iliopoulos D, et al. Genome-wide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome. // Neurogastroenterol Motil 2016;28:410-22.

file

download