44 -1 (25/2) 2019 — Yunusova Sh.A., Sharipova Sh.U., — ALGORITHM OF INSPECTION AND MAINTAINING PREGNANT WOMEN WITH THE GESTATIONAL THYROTOXICOSIS

ALGORITHM OF INSPECTION AND MAINTAINING PREGNANT WOMEN WITH THE GESTATIONAL THYROTOXICOSIS

Yunusova Sh.A., Bukhara state medical institute.

Sharipova Sh.U., Bukhara state medical institute.

Niyozova G.S. Bukhara state medical institute.

Resume,

In the present article for the purpose of studying of a biophysical profile of a fruit and levels of platsent specific a- микроглобулина (PAMG), a trophoblast specific b globulin (TBG), an alfo-fetoglobulin (AFP) and an estriol in the amniotic environment submitted the analysis of predictive signs on development of perinatal pathology in pregnant women with a gestational thyrotoxicosis. For forecasting of perinatal complications at women were the discriminant analysis is used. As the training matrix of supervision for creation of discriminant function 65 supervision, from them 30 women of the main group with a gestational thyrotoxicosis are taken, as control 35 women with the full-term, uncomplicated pregnancy are taken.

On the basis of results of inspection: data of KTG, doppler, biophysical profile of a fruit, biochemical and hormonal researches amniotic (about / п) liquids, and also on the basis of the revealed predictive criteria tactics of conducting childbirth is developed. Conducting childbirth at a gestational thyrotoxicosis according to the offered tactics will allow to lower considerably the birth of newborns in asphyxia and the level of perinatal complications.

Decrease in biophysical characteristics correlates with adverse perinatal outcomes. Research of level of proteins and hormones of the amniotic environment confirms existence of a hypoxia of a fruit. Existence of correlative communications of a biophysical profile of a fruit, PAMG, TFG, AFP and estriol proves their high importance for forecasting of perinatal complications.

The developed predictive criteria, algorithm of inspection and tactics of conducting childbirth at a gestational thyrotoxicosis will allow to reveal in due time a pathological condition of a fruit, to choose an optimum method of to make childbirth and to reduce the level of perinatal complications.

Application of mathematical methods in practical activities of doctors for assistance concerning forecasting of possibility of development of complications at pregnancy, childbirth, the postnatal period is perspective, convenient and reliable. Conducting childbirth at a gestational thyrotoxicosis according to the offered tactics will allow to lower considerably the birth of newborns in asphyxia and the level of perinatal complications.

Keywords: perinatal complications, thyrotoxicosis, gestational thyrotoxicosis

First page

170

Last page

173

For citation: Yunusova Sh.A., Sharipova Sh.U., Niyozova G.S. Algorithm of inspection and maintaining pregnant women with the gestational thyrotoxicosis//New Day in Medicine 1(25)2019 170-173 https://cutt.ly/VbFgbMH

List of References

1. Петрова В.Н. Взаимосвязь тиреоидной и фетоплацентарной систем у беременных, проживающих в условиях природного йодного дефицита / В.Н. Петрова и др. // Акушерства и гине­кология. 2007. – №4. – С. 30-33.
2. Вчерашнюк С.П. Влияние ТЭС-терапии на гормональный го­меостаз и микроциркуляцию у беременных с гестозом: авто- реф. дис. □ канд. мед. наук / С.П. Вчерашнюк. – Краснодар, 2011. – 23 с.
3. Каримова Ф.Д. Критерии перинатальных осложнений, алго­ритм обследования и ведения беременных с гестационным тиреотоксикозом / Ф.Д. Каримова, Ш.А. Юнусова // Врач- аспирант. – 2012. – № 3. – С. 84-87.
4. Султонова Н.А., Факторы риска развития преэклампсии у беременных и пути её снижения / Н.А. Султонова, Э.Р. На­врузов, Ю.Г. Расульзаде // Наука молодых (Eruditio Juvenium). – 2015. -№2. – С.67-74.
5. Фадеев В.В. Диагностика и лечение заболевания щитовидной железы во время беременности и в послеродовом периоде: по материалам клинических рекомендаций эндокринологи­ческой ассоциации США / В.В. Фадеев // Thyronet. – 2007. – №1. – С.1-9.
6. Цивцивадзе Е.Б., Петрухин В.А., Бурумкулова Ф.Ф. Особен­ности течения гестоза и профилактика его тяжелых форм у беременных с болезнью Грейвса. // Конференция молодых ученных и специалистов “Актуальные вопросы клинической и экспериментальной медицины – 2007” Санкт-Петербург 2007.
7. Цивцивадзе Е.Б. Профилактика и прогнозирование тяжелых форм гестоза у беременных с тиреотоксикозом: автореф. дис… канд. мед. наук / Е.Б. Цивцивадзе Е.Б. -Москва, 2007. -24 с.
8. Чикин В.Г., Пчелинцев В.В. Изменения синтеза протеинов беременности при некоторых клинических проявлениях ма­точно-плацентарной недостаточности // Рос. мед. -биол. вести. им. акад. И.П. Павлова. 2012. №3 С.27-32.
9. Blackwell S.C. Meconium aspiration syndrome in term neonates with normal acid-base status at delivery: is it different? / S.C. Blackwell, J. Moldenhauer, S. Hassan et al. // Am. J. Obstet. Gynecol. – 2001. – Vol. 18, №7. – Р. 422-425.
10. Klingner M. Meconium aspiration syndrome: pathophysiology and prevention / M. Klingner, J. Kruse // J. Am. Board Fam. Prac. – 1999. – Vol. 6, №3. – Р. 180-183.