73 -1 (25/2) 2019 — Narziev I.I., Oblokulov A.A., — EFFICIENCY OF ANTI-VIRUS TREATMENT OF HCV-INFECTION

EFFICIENCY OF ANTI-VIRUS TREATMENT OF HCV-INFECTION

Narziev I.I., Bukhara State Medical Institute named after Abu Ali ibn Sino.

Oblokulov A.A., Bukhara State Medical Institute named after Abu Ali ibn Sino.

Farmanova M.A., Bukhara State Medical Institute named after Abu Ali ibn Sino.

Elmuradova A.A., Bukhara State Medical Institute named after Abu Ali ibn Sino.

Abdullaev M.O. Bukhara State Medical Institute named after Abu Ali ibn Sino.

Resume,

There were studied epidemiological features of patients with HCV-infection who were under dispensary observation in clinics located in Bukhara Region, number of patients was 319, 110 (34.5%) of them were men and 209 (65.5%) were women. Etiological diagnostics of Chronic Hepatitis C was performed by the development of RNA and genotype of HCV infection in blood serum by the method of real-time polymerase chain reaction. It was detected that 63.9% (n. 204) of the patients had first, 0.5% (n = 18) of them had second, 21.9% (n =70) – third, 0.8% (n = 27) – fourth genotype of the virus. Before antiviral therapy, in 22 (20%) in the main group of patients it was detected F0 fibrosis, so in 30 (27%) patients F1, in 36 (31.8%) patients F2 and in 23 (21%) patients F3. Fibrosis of F4 stage was revealed only in 2 (0.2%) patients. With the use of sofosbovir + ledipasvir, rapid virologic response was observed in 195 (95.6%) patients, early virological response – in 204 (100%), 200 (98%) of the patients achieved complete elimination of HCV RNA.

Key words: HCV-infection, fibroscan, sofosbovir, ledipasvir.

First page

274

Last page

276

For citation: Narziev I.I., Oblokulov A.A., Farmanova M.A., Elmuradova A.A., Abdullaev M.O. Efficiency of anti-virus treatment of hcv-infection//New Day in Medicine 1(25)2019 274-276 https://cutt.ly/Ab0zio4

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