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  • 56 -2 (26/2) 2019 — Masharipova M.C., Fayzullayeva N.Ya. — COMPARATIVE STUDY OF THE IMMUNE STATUS IN CHILDREN WITH CHRONIC AND ACUTE BRONCHITIS

56 -2 (26/2) 2019 — Masharipova M.C., Fayzullayeva N.Ya. — COMPARATIVE STUDY OF THE IMMUNE STATUS IN CHILDREN WITH CHRONIC AND ACUTE BRONCHITIS

COMPARATIVE STUDY OF THE IMMUNE STATUS IN CHILDREN WITH CHRONIC AND ACUTE BRONCHITIS

Masharipova M.C., Tashkent Pharmaceutical Institute, Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan.

Fayzullayeva N.Ya. Tashkent Pharmaceutical Institute, Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan.

Resume,

The purpose of the study was to study the immune and cytokine status in children with chronic and acute bronchitis in a comparative aspect. In children with acute bronchitis, an imbalance in the activity of the B-unit of the immune system was observed, which was expressed in a significant increase in CD20+ and CD23+ cells expression, decrease in immunoglobulin’s IgG and IgA, hyper production of IgM in relation to the data of the control group. It was established that the content of IL-1p and TNFa in children with acute and chronic bronchitis did not differ significantly between them, although in children with both nosological units this indicator was significantly increased compared with the data of healthy children. In terms of IL-6 and IL-8, the parameters of sick children were significantly higher than the control data. Indicators of these cytokines in children with chronic bronchitis were significantly lower than the parameters of children with acute bronchitis.

Keywords: chronic bronchitis in children, non-specific defense factors, parasitic invasion, immune and cytokine status.

First page

209

Last page

213

For citation: Masharipova M.C., Fayzullayeva N.Ya. Comparative study of the immune status in children with chronic and acute bronchitis//New Day in Medicine 2(26)2019 209-213 https://cutt.ly/AbO0l7z

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