57 -2 (26/2) 2019 — Mirzaeva B.M., Daminov B. T. — VASCULAR CALCIFICATION IN PATIENTS WITH END-STAGE CHRONIC RENAL DISEASE

VASCULAR CALCIFICATION IN PATIENTS WITH END-STAGE CHRONIC RENAL DISEASE

Mirzaeva B.M., Tashkent Pediatric Medical Institute.

Daminov B. T. Tashkent Pediatric Medical Institute.

Resume,

In patients with CKD stage V, significant coronary calcification was detected, the severity of which correlates with impaired calcium-phosphorus metabolism an increase in parathyroid hormone, phosphorus, calcium-phosphorus product and alkaline phosphatase activity, and does not correlate with the role of CKD in coronary calcification vessels and, indirectly, to increase cardiovascular risk.

Keywords: end-stage chronic renal disease, vascular calcification, CT Ca-score, secondary hyperparathyreosis.

First page

214

Last page

216

For citation: Mirzaeva B.M., Daminov B. T. Vascular calcification in patients with end-stage chronic renal disease//New Day in Medicine 2(26)2019 214-216 https://cutt.ly/IbO0mzy

List of References

1. London G., Gu?rin A., Marchais S.J., M?tivier F., Pannier B., Adda H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. //Nephrol Dial Transplant 18: 1731-1740, 2003
2. Russo D, Corrao S, Battaglia Y, Andreucci M, Caiazza A, Carlomagno A, Lamberti M, Pezone N, Pota A, Russo L, Sacco M, Scognamiglio B. Progression of coronary artery calcification and cardiac events in patients with chronic renal disease not receiving dialysis. //Kidney Int 80: 112-118, 2011
3. London G.M. Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function. //J Am Soc Nephrol 14: S305-S309, 2003
4. Mizobuchi M, Towler D, Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. //J Am Soc Nephrol 20: 1453-1464, 2009
5. Giachelli C.M. Vascular calcification mechanisms. //J Am Soc Nephrol 15: 2959-2964, 2004
6. Ross R. Atherosclerosis-an inflammatory disease. //N Engl J Med 340: 115-126, 1999
7. Shroff R.C., McNair R., Figg N., Skepper J.N., Schurgers L, Gupta A, Hiorns M, Donald A.E., Deanfield J, Rees L, Shanahan C.M. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. //Circulation 118: 1748­1757, 2008
8. Pai A, Leaf E.M., El-Abbadi M, Giachelli C.M. Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. //Am J Pathol 178: 764-773, 2011
9. Pai A.S, Giachelli C.M. Matrix remodeling in vascular calcification associated with chronic kidney disease. //J Am Soc Nephrol 21: 1637-1640, 2010
10. .Lau W.L., Pai A, Moe S.M., Giachelli C.M. Direct effects of phosphate on vascular cell function. //Adv Chronic Kidney Dis 18: 105-112, 2011
11. Shobeiri N, Adams M.A, Holden R.M. Phosphate: an old bone molecule but new cardiovascular risk factor. //Br J Clin Pharmacol 77: 39-54, 2014
12. Giachelli C.M. The emerging role of phosphate in vascular calcification. //Kidney Int 75: 890-897, 2009
13. Kestenbaum B, Sampson J.N, Rudser K.D, Patterson D.J, Seliger S.L, Young B, Sherrard D.J, Andress D.L. Serum phosphate levels and mortality risk among people with chronic kidney disease. //J Am Soc Nephrol 16: 520-528, 2005
14. Wen P, Cao H, Fang L, Ye H, Zhou Y, Jiang L, Su W, Xu H, He W, Dai C, Yang J. miR-125b/Ets1 axis regulates transdifferentiation and calcification of vascular smooth muscle cells in a high-phosphate environment. //Exp Cell Res 322: 302-312.