55 -3 (27/2) 2019 — Nurbayev F.E., Djumaev B.Z. — VALUE OF GENES IN ORGANISM OF MAN IN OVENWEIGHT AND OBESITY
VALUE OF GENES IN ORGANISM OF MAN IN OVENWEIGHT AND OBESITY
Nurbayev F.E. Bukhara State Medical institute named after Abu Ali Ibn Sina.
Djumaev B.Z. Bukhara State Medical institute named after Abu Ali Ibn Sina.
Resume,
Thus, the results of the study and literature show that in реор1е who are overweight and obese, the essence of genes is not fully studied, and it is exgected that a number ofрroblems associated with the study of these genes will solve them. Gene analysis is рerformed once in a lifetime, as it does not change over age, so based on the analysis of genetic data it is necessary to formulate dietary рrocedures aimed at рreventing overeating. One such major global рroblem is the study of genes that тр»ш1 to overweight and obesity. Uzbekistan’s medical р^ай^ has not develoрed ways to identify and correct genes that are overweight and obese. Further scientific research is needed to eliminate the above-mentioned indues, as the detection of excess body weight and genes in obesity and the рrevention of diseases caused by obesity are imрortant for medical рractice.
Key words: Overweight, dangerous obesity, obesity, randomization, motivation, gene mutation, рolymorрhic variants of genes, triglycerides, aрoliрoрroteins A and B, arterial hyрertension, ischemic stroke, Townsend index.
First page
206
Last page
210
For citation: Nurbayev F.E., Djumaev B.Z. Value of genes in organism of man in ovenweight and obesity//New Day in Medicine 3(27)2019 206-210 https://cutt.ly/AbxKExs
List of References
- Солнцева А.В., Е.А. Аксенова, А.В. Сукало, Гендерные различия и генетический полиморфизм адипонектина у детей 2010; 221-226 [Solnseva A.V., E.A. Aksenova, A.V. Sukalo, Gendernie razlichiya i geneticheskiy роишогЕ/ш adiрonektina u detey 2010; 221-226] [In Russ].
- Романцов М.Г., Горячева Л.Г., Коваленко А.Л. – Противовирусные и иммунотропные препараты в детской практикем 2011; Кн. 2: 744 [Romansov M.G., Goryacheva L.G., Kovalenko A.L. – Protivovirusnbie immunopnie рreрaratы v detskoy proktikam 2011; Kn. 2: 744 s] [In Russ]
- Нетребенко, текст научной статьи на тему “генетика и эпигенетика ожирения” успехи современной биологии, 2015; 135(2): 128-138 [Netrebenko, tekst nauchnoy stati na temu “genetika i eрigenetika ojireniya” usрexi sovremennoy biologii, 2015; 135(2): 128-138] [In Russ].
- Бессесен Д. Г., Кушнер Р. Избыточный вес и ожирение: Профилактика, диагностика и лечение. – М.: ЗАО”Изд-во БИНОМ”. – 2004; 240-241 [Bessesen D. G., Kushner R. Izbitochniy ves i ojirenie: Profilaktika, diagnostika i lechenie. – M.: ZAO”Izd- vo BINOM”. 2004; 240-241] [In Russ].
- Бирюкова Е. В. Молекулярно-генетические, гормонально-метаболические и клинические аспекты метаболического синдрома. Авт. дис… докт. – М., 2009; 40. [Biryukova E. V. Molekulyarno- geneticheskie, gormonalno-metabolicheskie i klinicheskie asрekti metabolicheskogo sindroma. Avt. Dis… Dokt. – M., 2009; 40.].
- Ожирение и избыточный вес. Информационный бюллетень ВОЗ. №311. Май 2014 г. httр://www.who.int/mediacentre/ factsheets/fs311/ru/. Ссылка активна на 29.06.2016. [Obesity and overweight. Fact sheet. Updated June 2016. WHO Media centre. 2016.]
- Насибулина Э.С. Ассоциация полиморфизма гена fto с избыточной массой тела в российской популяции // Казанский медицинский журнал. – 2012; 93(5): 823-826 [Nasibulina E.S. Assotsiatsiya рoliшorfizma gena fto s izbbitochnoy massoy tela v rossiyskoy populyasii // Kazanskiy meditsinskiy jurnal. 2012; 93(5): 823-826.][In Russ].
- Центр СМИ BO3. Ожирение и избыточный вес. Информационный бюллетень. 16 февраля 2018; – https://www.who.int/ru/ news-room/fact-sheets/detail/obesity-and-overweight (дата обра- нгеиия: 03.03.2019). [Sentr CMI BOZ. Ojirenie i izbitochniy ves. Informatsionniy byulleten. 16 fevralya 2018; https://www.who.int/ ru/news-room/fact-sheets/detail/obesity-and overweight (data obrasheniya: 03.03.2019)].
- Dina C., Meyre D., Gallina S. еt al. Variation in FTO contributes to childhood obesity and severe adult obesity // Nat. Genet. 2007; 39: 724-726.
- Frayling T.M., Timpson N.J., Weedon M.N. еt al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity // Science. 2007; 316: 889-894.
- Liu C.T. еt ай Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (C^ARGE) Consortium Targeted Sequencing Study //Circulation: Cardiovas-cular Genetics. 2014; 7(3): 344-349.
- Livingstone K.M. еt ай FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials//bmj. 2016; 354: 14707.
- Locke A.E. еt ай. Genetic studies of body mass index yield new insights for obesity biology //Nature. 2015; 518(7538): 197-206.
- Loos R. J. F. еt ай Common variants near MC4R are associated with fat mass, weight and risk of obesity //Nature genetics. 2008; 40(6): 768-775.
- Ng M. еt ай Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: а systematic analysis for the Global Burden of Disease Study 2013 //The lancet. 2014; 384(9945): 766-781.
- Yeo G.S. H. The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition //Molecular and cellular endocrinology. – 2014; 397(1-2): 34-41.
- Nieters A., Becker N., Linseisen J. Polymo^hisms in candidate obesity genesand their interaction with dietary intake of n-6 polyunsaturated fatty acids affectobesity risk in a sub-sample of the EPIC-Heidelberg cohort. Eur. J. Nutr. 2002; 41(5): 210-21.
- Mamm?s O., Betoulle D., Aubert R., Herbeth B., Siest G., Fumeron F. Associationof the G-2548A polymorphism in the 5′ region of the LEP gene with overweight.Ann. Hum. Genet. 2000; 64(Pt 5): 391-4.
- Beate K., Joseph N., Nicolas de R., Wolfram K. Genetics of isolated hypogonadotropic hypogonadism: role of GnRH receptor and other genes. Int. J. Endocrinol. 2012; 2012: 147893.
- Vask? J.A., Vask? A., Dost?lov? Z., Bienert P. Association of le|)tin genetic polymorphism -2548 G/A with gestational diabetes mellitus. Genes Nutr. 2006; 1(2): 117-23.