• Home
  • NEW DAY MEDICINE
  • 2 (30) 2020
  • 76 -2 (30/2) 2020 — Azizova G.D., Azizova D.Sh. — MARKERS OF BONE METABOLISM AND VITAMIN D LEVELS IN WOMEN OF REPRODUCTIVE AGE WITH HYPOESTROGENIA

76 -2 (30/2) 2020 — Azizova G.D., Azizova D.Sh. — MARKERS OF BONE METABOLISM AND VITAMIN D LEVELS IN WOMEN OF REPRODUCTIVE AGE WITH HYPOESTROGENIA

MARKERS OF BONE METABOLISM AND VITAMIN D LEVELS IN WOMEN OF REPRODUCTIVE AGE WITH HYPOESTROGENIA

Azizova G.D., -Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Tashkent, Uzbekistan, 100124, Tashkent, Mirzo-Ulugbek district, Mirzo-Ulugbek St., 132-a Website: www.akusherstvo.uz Ministry of Health of the Republic of Uzbekistan, 100000 Tashkent, Amir Temur str. 6 https://www.minzdrav.uz.

Azizova D.Sh., -Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Tashkent, Uzbekistan, 100124, Tashkent, Mirzo-Ulugbek district, Mirzo-Ulugbek St., 132-a Website: www.akusherstvo.uz Ministry of Health of the Republic of Uzbekistan, 100000 Tashkent, Amir Temur str. 6 https://www.minzdrav.uz.

Ashirmetov A.H., -Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Tashkent, Uzbekistan, 100124, Tashkent, Mirzo-Ulugbek district, Mirzo-Ulugbek St., 132-a Website: www.akusherstvo.uz Ministry of Health of the Republic of Uzbekistan, 100000 Tashkent, Amir Temur str. 6 https://www.minzdrav.uz

Ismailova Z.I., -Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Tashkent, Uzbekistan, 100124, Tashkent, Mirzo-Ulugbek district, Mirzo-Ulugbek St., 132-a Website: www.akusherstvo.uz Ministry of Health of the Republic of Uzbekistan, 100000 Tashkent, Amir Temur str. 6 https://www.minzdrav.uz.

 Azimova E.I., -Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Tashkent, Uzbekistan, 100124, Tashkent, Mirzo-Ulugbek district, Mirzo-Ulugbek St., 132-a Website: www.akusherstvo.uz Ministry of Health of the Republic of Uzbekistan, 100000 Tashkent, Amir Temur str. 6 https://www.minzdrav.uz.

Resume,

The women of reproductive age with hypoestrogenia of various origins, significant changes in bone metabolism occur, characterized by the prevalence of the destruction process over bone synthesis. Namely, the value of р – CrossLaps was 1,5 times higher than normal (0,83 ± 0,03ng / ml), while markers of bone formation remained within normal limits. In assess of vitamin D blood concentration only 4 (15,4%) participants of our study had a normal level of vitamin D in the blood, the insufficiency of this necessary vitamin was detected in 12 (46,2%), deficiency in 9 (34,6%), which was more than a third of women, distinct deficit was in 1 (3,8%).

Key words: hypoestrogenism, biochemical markers of bone, reproductive age, vitamin D.

First page

296

Last page

298

For citation: Azizova G.D., Azizova D.Sh., Ashirmetov A.H., Ismailova Z.I., Azimova E.I., Markers of bone metabolism and vitamin d levels in women of reproductive age with hypoestrogenia//New Day in Medicine 2(30)2020 296-298 https://cutt.ly/QvsiUoT

List of References

  1. Кузнецова И.В., Успенская Ю.Б. Остеопороз у молодых жен­щин со стойким дефицитом эстрогенов. // Ж Российский вестник акушера-гинеколога. 2010; 3.
  2. Положаева И.В., Алиякпаров М.Т. Актуальность проблемы остеопороза в молодом возрасте и его ранней современной диагностики // Международный журнал прикладных и фун­даментальных исследований. 2018; 2: 115-120.
  3. Eastell R., O’Neill T.W., Hofbauer L.C., Langdahl B., Reid I.R., Gold D.T., Cummings S.R. Postmenopausal osteoporosis. Nature reviews Disease primers. 2016; 2(): 60-69.
  4. Macari S., Ajay Sharma L., Wyatt A., Knowles P., Szawka R.E., Garlet G.P., Grattan D.R., Dias G.J., Silva T.A. Osteoprotective effects of estrogen in the maxillary bone depend on ERalpha. // J Dent Res. – 2016; 95(6): 689-696.
  5. Eastell R., Christiansen C., Grauer A. et al. Effects of denosumab on bone turnover markers in postmenopausal osteoporosis // JBMR. -2011; 26(3): 530-537.
  6. Sahana Shetty., Nitin Kapoor., Joseph Dian Bondu, et al. Bone turnover markers: emerging tool in the management of osteoporosis // Indian Journal Endocrinol Metab. – 2016; 20(6): 846-852.
  7. Калинченко С.Ю., Пигарова Е.А., Гусакова Д.А., Плещева А.В. Витамин D и мочекаменная болезнь. // Consilium Medicum. 2012; 14(12): 97-102.
  8. Cranney C., Horsely T., O’Donnell S., Weiler H., Ooi D., Atkinson S., et al. Effectiveness and safety of vitamin D. Evidence Report /Technology Assessment No. 158 prepared by the University of Ottawa Evidence-based Practice Center under Contract No. 290-02.0021. AHRQ Publication No. 07-E013. Rockville, MD: Agency for Healthcare Research and Quality, 2007.
  9. Holick M.F. Vitamin D deficiency. // N Engl J Med 2007; 357: 266-81.
  10. Mithal A. Treatment of vitamin D deficiency. Endocrine case management ICE/ENDO 2014 Meet-th- professor, Endocrine society 2014; 37-39.
  11. Mithal A., Wahl D.A., Bonjour J.P., Burckhardt P., Dawson- Hughes B., Eisman J.A., El-Hajj Fuleihan G., Josse R.G., Lips P., Morales-Torres J. (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807-182.
  12. Santoro N. Update in Hyper-and Hypogonadotropic Amenorrhea / N. Santoro // Clin. Endocrinol. Metab. – 2011; 96(11); 3281­3288.

file

download