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  • 40 -3 (31/1) 2020 — Boboev Q. T., Egamova S. Q. — CLINICAL, HEMATOLOGICAL AND MOLECULAR — GENETIC FEATURES OF ACUTE LEUKEMIA

40 -3 (31/1) 2020 — Boboev Q. T., Egamova S. Q. — CLINICAL, HEMATOLOGICAL AND MOLECULAR — GENETIC FEATURES OF ACUTE LEUKEMIA

CLINICAL, HEMATOLOGICAL AND MOLECULAR – GENETIC FEATURES OF ACUTE LEUKEMIA

Boboev Q. T. -Scientific Research Institute of Hematology and Blood Transfusion, Ministry of Health of the Republic of Uzbekistan, Bukhara State Medical Institute named after Abu Ali ibn Sina

Egamova S. Q. -Scientific Research Institute of Hematology and Blood Transfusion, Ministry of Health of the Republic of Uzbekistan, Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The review presents the epidemiology, etiopathogenesis, and main clinical manifestations of acute leukemia. The diagnostic criteria for verifying the diagnosis of acute leukemia and its variant based on the data of morphological, cytochemical, immunological and cytogenetic research methods are presented in detail. Modern trends in the classification of acute leukemias are given taking into account molecular biological analysis. Molecular genetic prognostic factors for lymphoblastic and non-lymphoblastic variants of acute leukemia are presented.

Key words: acute leukemia, blast cells, cytochemistry, cytogenetics.

First page

177

Last page

181

For citation: Boboev Q. T., Egamova S. Q.,Clinical, hematological and molecular – genetic features of acute leukemia//New Day in Medicine 3 (31)2020 177-181 https://cutt.ly/DxIcVM4

List of References

  1. Воробьев А.И. Руководство по гематологии. // Ньюдиамед. 2007. – Т1. – С.159-171.
  2. Ковынев И.Б., со авторы. Клинико – эпидемиологическая и молекулярно – генетическая характеристика острых лейко­зов во взрослой клинике Новосибирского городского гема­тологического центра // Сибириский медицинский журнал. – 2017. – №2. – С.62-65.
  3. Мисюрин А.В. Цитогенетические и молекулярно – генетичес­кие факторы прогноза острых миелоидных лейкозов // Кли­ническая онкогематология. – 2017;10(2). – С.226- 234.
  4. Окороков А.Н. Диагностика болезней внутренных органов. Диагностика болезней системы крови // М.: Мед. лит., 2001. – Т4. – С.205-270
  5. Рукавицин О.А. Гематология: национальное руководство // М.:ГЭОТАР-Медиа, 2015. С.180-199.
  6. Ходулева С. А., Кравченко Д. В. Современные аспекты лабо­раторной диагностики острых лейкозов // Проблемы здоро­вья и экологии. 2010. – С. 96-101.
  7. Arber DA, Borowitz MJ, Cessna M, et al. Initial diagnostic workup of acute leukemia: guideline from the College of American Pathologists and the American Society of Hematology // Arch Pathol Lab Med. 2017. 141:1342-1393.
  8. D?hner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel // Blood. 2017. 129:424-447
  9. Papaemmanuil E, Gerstung M, Bullinger L, et al. Genomic classification and prognosis in acute myeloid leukemia // N Engl J Med. 2016. 374:2209-2221.
  10. Walter RB, Othus M, Burnett AK, et al. Resistance prediction in AML: analysis of 4601 patients from MRC/ NCRI, HOVON/ SAKK, SWOG and MD Anderson Cancer Center // Leukemia.2015. 29:312-320.
40-177-181-3-31-2020-

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