90 -3 (31/2) 2020 — Mirzoeva M. — DEFICIENCY/INSUFFICIENCY OF VITAMIN D IN PATIENTS WITH PITYRIASIS ALBA: POSSIBLE ASSOCIATION WITH PATHOGENESIS OF THE DISEASE
DEFICIENCY/INSUFFICIENCY OF VITAMIN D IN PATIENTS WITH PITYRIASIS ALBA: POSSIBLE ASSOCIATION WITH PATHOGENESIS OF THE DISEASE
Mirzoeva M.,-Buxara State Medical Institute.
Resume
Pityriasis alba (PA) is common in countries with tropical and subtropical climate, including Uzbekistan. The
pathogenesis remains unknown and therefore the treatment is ineffective. The study is justified by the lack of information on the role of vitamin D in PA pathogenesis. The aim of the study is to determine the level of vitamin D in PA patients with evaluation of interrelations between vitamin D deficiency/insufficiency and the concentration of serum IgE and the possible role of vitamin D in the pathogenesis of PA. Vitamin D deficiency/insufficiency in PA patientsis detected in 92.7% of cases. The concentration of total serum IgE correlates with the degree of vitamin D level decrease. The highest IgE levels are determined in PA patients with vitamin D deficiency. It is recommended to monitor the level of vitamin D in PA patients. Correction of vitamin D deficiency/insufficiency in PA patientsis is mandatory.
Key words: Pityriasis alba, vitamin D, IgE.
First page
378
Last page
384
For citation: Mirzoeva M., Deficiency/insufficiency of vitamin d in patients with pityriasis alba: possible association with pathogenesis of the disease//New Day in Medicine 3(31)2020 378-384 https://cutt.ly/HxDXJKI
List of References
- Абдиев Т.А., Каримова М.Т., Умарова П.Х., Юлдашходжаев И.У., Улмасов М.М. Ситуация по гельминтно-протозойным болезням в Узбекистане // Вестник врача. – 2007. – №1. – С.75-76.
- Латыпов Р.Р. Сравнительная оценка эффективности некоторых противоэпидемических мероприятий в отношении основных кишечных паразитозов среди сельского населения Ферганской долины. Автореф….канд. мед. наук, Ташкент. – 2011. – 18с.
- BenagianoG, BenagianoM., Bianchi Р., D’Elios M.M., Brosens I. Contraception in Autoimmune Diseases. Best Pract Res Clin ObstetGynaecol Oct 2019 60, 111-123
- Cairncross C., Grant C.,Stonehouse W., Conlon C., McDonaldB, ,Houghton, Eyles D., Camargo C.A., Coad J., von Hurst P. The relationship [ between vitamin D status and allergic diseasesin New Zeland Preschool children. Nutrients. 20156. Jun1:8(5).pii: B326. doi 10. 3390/nu8-60326
- Chauhan K, Bhimji SS. Vitamin, D.StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2017 Jun-.2017 Jun 30.
- Chun RF, Liu PT, Modlin RL, et al. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 2014;5:151.doi:10.3389/fphys.2014.00151.
- Dhibar DP, Sahu KK, Bhadada SK. Vitamin D deficiency: Time for a reality check of the epidemiology. Re. “The increasing problem of sub clinical an d overt hyp ervitaminosis D in India: An institutional experience and review.” Nutrition. 2018 Jan;45:145. doi: 10.1016/j.nut.2017.04.007
- Ebeling PR. Vitamin D and bone health: epidemiologic studies. Bonekey Rep. 2014;3:511. doi: 10.1038/bonekey.2014.6. 4.
- Elio Kechichian, Khaled Ezzedine. Vitamin D and the Skin: An Update for Dermatologists.Am J Clin Dermatol. 2018. 19 (2, 223235
- El-Khateeb EA, Lotfi RA, Abd Elaziz KM, El-Shiekh SE. Prevalences of skin diseases among primary schoolchildren in Damietta, Egypt. Int J Dermatol. 2014;53(5).
- Fitzpatrick, T.B. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol. 1988;124(6):869-71.
- Ghafourian A, Ghafourian S, Sadeghifard N, et al. Vitiligo: symptoms, pathogenesis, and treatment. Int J Immunopathol Pharmacol 2014;27:485-9.
- Girgis CM, Clifton-Bligh RJ, Hamrick MW, et al. The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev. 2013;34:33-83. doi: 10.1210/er.2012-1012
- Girgis CM, Mokbel N, Cha KM, et al. The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology. 2014;155:3227-3237. doi: 10.1210/en.2014-1016.
- Givler DN, Givler A. Pityriasis, Alba. [Updated 2017 May 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2018.
- Givler D., Basit H., Amy Givler A. Pityriasis Alba. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.2019 Dec 30
- Grant WB, Whiting SJ, Schwalfenberg GK, Genuis SJ, Kimball SM. Estimated economic benefit of increasing 25-hydroxyvitamin D concentrations of Canadians to or above 100 nmol/L. Dermatoendocrinol.2016 Oct 14;8(1):e1248324. eCollection2016 Jan-Dec.
- Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
- Iffat Hassan, Yasmeen J. Bhat, Sabhiya Majid,1PeerzadaSajad, Farhan Rasool, Rawoof A. Malik, and Inam Ul Haq. Association of Vitamin D Receptor Gene Polymorphisms and Serum 25- Hydroxy Vitamin D Levels in Vitiligo – A Case-control Study.Indian Dermatol Online J. 2019 Mar-Apr; 10(2): 131-138.
- Jing-Zhan Zhang, Man Wang, Yuan Ding,aFeng Gao,Yan-Yan Feng, BuwajieerYakeya, Peng Wang, Xiu-Juan Wu, Feng-Xia Hu,Jun Xian, and Xiao-Jing Kang, Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo.Medicine (Baltimore). 2018 Jul; 97(29): e11506. Published online 2018 Jul 20. doi: 10.1097/MD.0000000000011506