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  • 107 -3 (31/3) 2020 — Rakhmonov N.H., Abdurakhmanov M.M., — DYNAMICS OF INDICATORS OF INNATE IMMUNITY IN PATIENTS WITH CHEST TRAUMA COMBINED WITH CRANIOCEREBRAL TRAUMA

107 -3 (31/3) 2020 — Rakhmonov N.H., Abdurakhmanov M.M., — DYNAMICS OF INDICATORS OF INNATE IMMUNITY IN PATIENTS WITH CHEST TRAUMA COMBINED WITH CRANIOCEREBRAL TRAUMA

DYNAMICS OF INDICATORS OF INNATE IMMUNITY IN PATIENTS WITH CHEST TRAUMA COMBINED WITH CRANIOCEREBRAL TRAUMA

Rakhmonov N.H. -Bukhara State Medical Institute.

Abdurakhmanov M.M. -Bukhara State Medical Institute.

Resume

Under the supervision there were 20 patients with chest trauma severe traumatic brain injury aged 19 to 68 years (mean age 37,3 ± 10,5 years). In the first 24 hours and 7 days after the injury, the patients underwent lumbar puncture with cerebrospinal fluid and peripheral blood sampling from the central vein. The quantitative contents of a – defensins in plasma and cerebrospinal fluid, cytokines in serum and CSF were determined by ELISA with a kit for determining human а– defensins and cytokines.

The results of the studies showed that severe head injury is accompanied by increased production of antimicrobial peptides (a-defensins – HNP 1-3), pro- and anti-inflammatory cytokines. The level of HNP 1-3 in plasma and CSF can serve as a prognostic criterion for the severity, course, and outcome of TBI.

Keywords: chest trauma, traumatic brain injury; cerebrospinal fluid; a-defensins (HNP 1-3); cytokines.

First page

447

Last page

451

For citation: Rakhmonov N.H., Abdurakhmanov M.M., Dynamics of indicators of innate immunity in patients with chest trauma combined with craniocerebral trauma//New Day in Medicine 3(31)2020 447-451 https://cutt.ly/QxFffMO

List of References

  1. Горбунов В.И., Ганнушкин И.В., под ред. Коновалова А.Н., Лихтермана Л.Б., Потапова А.А. Клиническое руководство по черепно-мозговой травме. Москва: Антидор, 2001. Том 1. 553 с.
  2. Гусев Е.И., Коновалов АН., Скворцова В.И., Гехт А.Б. Не­врология. Национальное руководство. Москва: ГЭОТАР-Ме- диа, 2009. 921 с.
  3. Дюкарев В.В., Юдина С.М., Королев А.Г. Особенности цито­кинового профиля сыворотки крови и ликвора у больных с черепно-мозговой травмой. Иммунопатология, аллергология, инфектология. 2018;3: 27-32
  4. Кокряков В.Н., Ковальчук Л.В., Алешина Г.М., Шамова О.В. Катионные противомикробные пептиды как молекулярные факторы иммунитета: мультифункциональность. Журнал мик­робиологии, эпидемиологии и иммунобиологии. 2006;2: 98105
  5. Коновалов АН., Лихтерман Л.Б., Потапов АА, под ред. Кли­ническое руководство по черепномозговой травме. Москва: Антидор, 1998. Том 1. 540 с.
  6. Конюченко Е.А, Ульянов В.Ю., Дроздова Г.А., Норкин И.А. Корреляционный анализ содержания а-дефензинов нейтро­филов 1-3 и цитокинов в плазме крови пациентов в остром и раннем периодах травматической болезни спинного мозга. Клиническая лабораторная диагностика. 2015; 60 (7): 53-55
  7. Dressier J., Hanisch U., Kuhlisch E., Geiger K.D. Neuronal and glial apoptosis in human traumatic brain injury. Int J Legal Med. 2007; 121(5): 365-375. DOI: 10.1007/s00414-006-0126-6
  8. Hellewell S.C., Morganti-Kossmann M.C. Guilty molecules, guilty minds? The conflicting roles of the innate immune response to traumatic brain injury. Mediators Inflamm. 2012; 2012: 356494. DOI: 10.1155/2012/356494.
  9. Hoge C.W., McGurk D., Thomas J.L. Mild traumatic brain injury in U.S. Soldiers returning from Iraq. N Engl J Med. 2008; 358(5): 453-463.DOI: 10.1056/NEJMoa072972
  10. Lehrer R.I., Lu W. а-Defensins in human innate immunity. Immunol Rev. 2012; 245(1): 84-112. DOI: 10.1111/j.1600- 065X.2011.01082.x.
  11. Loane D.J., Byrnes K.R. Role of microglia in neurotrauma. Neurotherapeutics. 2010; 7(4): 366-377. DOI: 10.1016/ j.nurt.2010.07.002.
  12. Maffei F.A., Heine R.P., Whalen M.J., Mortimer L.F., Carcillo J.A Levels of antimicrobial molecules defen- sin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis. Pediatrics. 1999. 103(5 Pt 1): 987-992. DOI: 10.1542/peds.103.5.987Ramlackhansingh A.F., Brooks D.J., Greenwood R.J., Bose S.K., Turkheimer F.E., Kinnunen K.M., Gentleman S., Heckemann R.A., Gunanayagam K., Gelosa G., Sharp D.J. Inflammation after trauma: Microglial activation and traumatic brain injury. Ann Neurol. 2011 Sep; 70(3):374-83DOI: 10.1002/ ana.22455
  13. Van Wetering S., Mannesse-Lazeroms S.P., Van Sterkenburg M.A., Daha M.R., Dijkman J.H., Hi- emstra P.S. Effec of defensins on interleukin-8 synthesis in airway epithelial cells. Am J Physiol. 1997; 272(5 Pt 1): L888-896. DOI: 10.1152/ ajplung.1997.272.5.L888
  14. Weckbach S., Neher M., Losacco J.T., Bolden A.L., Kulik L., Flierl M.A., Bell S.E., Holers V.M., Stahel P.F. Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotectionafter closed heiad injury. J Neurotrauma. 2012; 29(6): 1233-1242. DOI: 10.1089/neu.2011.2169
  15. Woodcock T., Morganti-Kossmann M.C. The role of markers of inflammation in traumatic brain injury. Front Neurol. 2013; 4: 18. DOI: 10.3389/fneur.2013.00018
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