161 -3 (31/4) 2020 — Yuldasheva S.Z., — APPLICATION OF NEW METHODOLOGICAL APPROACHES TO IMPROVE THE EFFICIENCY OF ASSISTED REPRODUCTIVE TECHNOLOGIES
APPLICATION OF NEW METHODOLOGICAL APPROACHES TO IMPROVE THE EFFICIENCY OF ASSISTED REPRODUCTIVE TECHNOLOGIES
Yuldasheva S.Z.,-Tashkent Pediatric Medical Institute.
Resume
The use of modern high-tech techniques for selecting gametes and embryos allows one to choose an embryo that has the highest chances of implantation. The goal of ART is the birth of one healthy child. In this regard, the tasks of clinical embryology are the creation, implementation and use in practical medicine of techniques that allow the screening to determine the most competent embryo for the birth of a healthy child. The use of the new unique technology of continuous video surveillance allows TimeLapse to evaluate the individual features of the morphodynamics and morphokinetics of each developing embryo. Thanks to continuous in vitro microscopy, it is possible to record the main events of early cell crushing, the formation of blastocysts. Another type of screening, which in recent years has become more widely used in medicine – is genetic screening for aneuploidy of embryos.According to different authors, the level of aneuploidy in developing embryos is up to 70%. The transfer of a genetically ’heatthy” embryo to the uterine cavity can reduce the waiting time for the birth of a healthy child and is aimed at preventing the birth of children with genetic diseases.
Key words: embryos, human, cultivation, genetic screening
First page
664
Last page
667
For citation: Yuldasheva S.Z., Application of new methodological approaches to improve the efficiency of assisted reproductive technologies//New Day in Medicine 3(31)2020 664-667 https://cutt.ly/NxLrnoL
List of References
- Глинкина Ж.И., Курцер М.А., Будник И.В. Исследование хромосомной патологии в клетках неразвивающегося хориона методом высокопроизводительного секвенирования. /Доктор. Ру №7. 2017.
- Джамалудинова А. Ф., Гонян М. М. Репродуктивное здоровье населения России. //Молодой ученый. №14 – 2, 2017.
- Доклад Секретариата ВОЗ. Борьба с генетическими заболеваниями. Сессия 116, 2005.
- Кузнецов В.Н., Рыбаковский Л.Л. Стратегия демографического развития России. /М., ЦСП.: 2005.
- Леваков С.А., Павлова С.А., Бугрова Т.И., Кедрова А.Г. Современный взгляд на бесплодный брак. //Клиническая практика №3, 2010.
- Русанова H.E. Репродуктивные возможности демографического развития. /М, “Спутник плюс”, 2008.
- Шурыгина О.В., Щелочков А.М., Сараева Н.В., Кулакова О.В., Юлдашева С.З., Новые методологические подходы в культивировании и молекулярной диагностике эмбрионов человека. //Вестник новых медицинских технологий. №4, 2018
- Fiorentino F., Biricik A., Bono S, Spizzichino L., Cotroneo E., Cottone G., Kokocinski F., Michel C.E. Development and validation of a next-generation sequencing-based protocol for 24- chromosome aneuploidy screening of embryos. Fertil. Steril., 2014
- Handyside A.H.Preimplantation genetic diagnosis after 20 years. Reprod Biomed Online. 2010
- Hansen M., Kurinczuk J.J., Bower C., Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N.Engl.J.Med. 2002
- Harper J.C., SenGupta S.B. Preimplantation genetic diagnosis: State of the ART 2011. Hum Genet. 2012.
- Liberman R.F., Getz K.D., Heinke D., Luke B., Stern J.E., Declerq E.R., Chen X., Lin A.E., Anderka M. Assisted Reproductive Technology and Birth Defects: Effects of Subfertility and Multiple Births.BirthDefectsRes. 2017
- PGDIS position statement on chromosome mosaicism and preimplantation aneuploidy testing at the blastocyst stage. PGDIS Newsletter, July 19, 2016
- Sahoo T., Dzidic N., Strecker M.N., Commander S., Travis M.K., Doherty C., Tyson R.W., Mendoza A.E., Stephenson M., Dise C.A., Benito C.W., Ziadie M.S., Hovanes K. Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges. Genet Med. 2017.