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  • 105 -4 (32/3) 2020 — Khalimova Z.U., Safarova Sh.M. — GENDER AND AGE CHARACTERISTICS OF MUSCULOSKELETAL COMPLICATIONS OF ACROMEGALIA

105 -4 (32/3) 2020 — Khalimova Z.U., Safarova Sh.M. — GENDER AND AGE CHARACTERISTICS OF MUSCULOSKELETAL COMPLICATIONS OF ACROMEGALIA

GENDER AND AGE CHARACTERISTICS OF MUSCULOSKELETAL COMPLICATIONS OF ACROMEGALIA

Khalimova Z.U. -Republican Specialized scientific Practical Medical Center of Endocrinology named after Academician Y.K.Turakulov, Tashkent Neyroendocrinology and hypophysis syrgery laboratory Republic Specialized Scientific-Practical Medical Centre of Endocrinology named after academician Ya.Kh.Turakulov, 100125, Mirzo Ulugbek street, Tashkent, Uzbekistan.

Safarova Sh.M. -Republican Specialized scientific Practical Medical Center of Endocrinology named after Academician Y.K.Turakulov, Tashkent Neyroendocrinology and hypophysis syrgery laboratory Republic Specialized Scientific-Practical Medical Centre of Endocrinology named after academician Ya.Kh.Turakulov, 100125, Mirzo Ulugbek street, Tashkent, Uzbekistan.

Kholikova A.O. -Republican Specialized scientific Practical Medical Center of Endocrinology named after Academician Y.K.Turakulov, Tashkent Neyroendocrinology and hypophysis syrgery laboratoryRepublic Specialized Scientific-Practical Medical Centre of Endocrinology named after academician Ya.Kh.Turakulov, 100125, Mirzo Ulugbek street, Tashkent, Uzbekistan.

Resume

The objective of our research was to study interrelation of acromegaly musculoskeletal complications development dependent on age, gender of patients, and the duration of the disease. The subject of the study were 110 patients with GH pituitary adenoma, who applied to the RSSPMCE within the period from 2000 to 2020 and were registered as patients with acromegaly in the RUz. Among them there were 40 (33.37%) men and 70 (63.63%) women. The mean age of the patients was 43±8.7 years old. In young age there was higher prevalence rate of osteoarthritis (49% versus 10.5%, p<0.001) and osteopenia (33.9% versus 13.2%, p<0.01). Patients with acromegaly had a high rate of musculoskeletal complications, in the structure of which a significant part is attributed to osteoporosis (60.9%) and osteoarthrosis (58.2%), with prevailing osteoarthrosis among female patients (60.5% versus 46.8%, p<0.05), and compression vertebral fractures among  males  (12.8% versus 5.5%, p<0.001).  With   the aging of patients  lesions of skeletal system become more severe developing to osteoporosis, osteoarthrosis, and fractures. With the increase in the duration of the disease hypersecretion of GH caused deterioration of MSC and growth of osteoarthrosis (92.5% with duration 10-19 years, p<0.001 and 94.3% with duration 20 years and more, p<0.001) and osteoporosis (91.2% with duration      10-19 years, p< 0.001and 98.3% with duration    20 years and more, p<0.001)   prevalence  rate. These findings confirm the necessity of early aggressive therapy of both basic disease and initial complications in musculoskeletal system, as alterations in joints and cartilages become irreversible with aging of the patients and increase of the disease duration.

Key words: acromegaly, osteoarthrosis, osteoporosis, musculoskeletal complications.

First page

414

Last page

419

For citation: Khalimova Z.U., Safarova Sh.M., Kholikova A.O., Gender and age characteristics of musculoskeletal complications of acromegalia//New Day in Medicine 4(32)2020 414-419 https://cutt.ly/Lz2bgWb

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105-414-418-4-32-2020-тиббиёт-25-12-2020-—-копия

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