153 -4 (32/3) 2020 — Nurboev F.E., Dzhumaev B.Z. — DETERMINATION OF GENES AND GENOTYPE OF POLYMORPHISM, LIPID SPECTRUM IN PATIENTS WITH OVERWEIGHT AND OBESITY

DETERMINATION OF GENES AND GENOTYPE OF POLYMORPHISM, LIPID SPECTRUM IN PATIENTS WITH OVERWEIGHT AND OBESITY

Nurboev F.E. -Bukhara State Medical Institute.

Dzhumaev B.Z. -Bukhara State Medical Institute.

Resume

The study was conducted on 46 overweight patients hospitalized in 2019 in various departments of the Bukhara Regional Multidisciplinary dinical Hospital.They were studied in three groups and the following results were obtained.Among the 7 types of genotypes, 3 genes in the polymorphism of genes and genotypes in diseases of the musculoskeletal system and cardiovascular system,Trp / Trp genotype ADRB3 (rs4994) _Trp64Arg gene was the most common in primary and control groups, С / С genotype of PPARG2 gene (rs1801282) _С34(1 was relatively moderate in the main control group.The A / A genotype of the ADRDB2 gene (rs1042713) A ^л G was less common than the Trp / Trp and С / С genotypes. The G / G genotype of the remaining PPARG2 gene (rs1801282) _С34(1 was found in 1 patient in the main group and in 2 patients in the control group. The G / G genotype of the PPARG2 (rs1801282) _С34(1 gene was several times less common                than the other С / G and С / С genotypes in both systemic diseases.Thus, in all 7 genotypes of the three genes of cardiovascular diseases, the levels of cholesterol, HDL, and LDL were higher in the base group and lower in the control group. Thus, the amount of cholesterol, HDL, LDL in diseases of the cardiovascular system was the highest in diseases of the cardiovascular system.

Key words: overweight, obesity, HDL and LDL, genes and genotypes, cardiovascular system, musculoskeletal system, lipids.

First page

547

Last page

552

For citation: Nurboev F.E., Dzhumaev B.Z., Determination of genes and genotype of polymorphism, lipid spectrum in patientswith overweight and obesity//New Day in Medicine 4(32)2020 547-552 https://cutt.ly/6z96F2A

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