155 -4 (32/3) 2020 — Latipov I.I. — EFFICACY OF METOTREXATE IN TREATMENT OF VITILIGO
EFFICACY OF METOTREXATE IN TREATMENT OF VITILIGO
Latipov I.I. –Bukhara State Medical Institute, Bukhara, Uzbekistan.
Resume
Vitiligo is a disorder of depigmentation resulting from the destruction of melanocytes in theepidermis.Mainstay oftreatment in unstable vitiligo are systemic steroids andphototherapy.As steroids have many complications andphototherapy being cost prohibitive methotrexate is tried as steroid sparing therapy in present study. It is a prospective Institutional studyconductedfrom September 2019 to April 2020 in individuals’ diagnosed (clinically) as unstable vitiligo. A total of 20 patients were enrolled in the study.
Key words: vitiligo, methotrexate, depigmentation, phototherapy, repigmentation.
First page
556
Last page
559
For citation: Latipov I.I., Efficacy of metotrexate in treatment of vitiligo//New Day in Medicine 4(32)2020 556-559 https://cutt.ly/bz3qB3w
List of References
- Mosher D. B., Fitzpatrick T. B., Ortonne J. P., et al. Disorders of melanocytes. In: Fizpatrick T. B., Eisen A. Z., Wolff K., etal,editors. Dermotology in General Medicine. 5th. New York, NY, USA: McGraw-Hill; 1999. pp. 945-1017
- Halder R. M., Taliaferro S. J. Vitiligo. In: Goldsmith L. A., Katz S. I., Gichrest B. A., Paller A. S., Leffell D. J.,editors. Fitzpatrick’s Dermatology in General Medicine. 7th. New York, NY, USA: McGraw-Hill; 2008. P. p. 616.
- Bystryn J. C. Theories in the pathogenesis of depigmentation: immune hypothesis. In: Hann S. K., Jeds J., editors. Vitiligo: AMonograph on the Basic and Clinical Science. Blackwell Science; 2000. pp. 129-136
- Birol A., KisaU., Kurtipek G.S. Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels inthelesional skin of patients with nonsegmental vitiligo. Int. J. Dermatol. 2006; 45(8):992-993
- Dell’anna M.L., Picardo M. A review and a new hypothesis for nonimmunologicalpathogenetic mechanisms in vitiligo. Pigm. CellRes. 2006; 19(5):406-411
- Rudwaleit M., Yin Z., Siegert S. Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cellderived tumour necrosis factor alpha, increase of interleukin 10, and predicted by the initial concentration of interleukin 4. Ann.Rheum. Dis. 2000; 59:311-314.
- Kim SM, Lee HS, Hann 5K. The efficacy of low-dose oral corticosteroids in the treatment of vitiligo patients. Int J Dermatol 1999; 38: 546-550
- Njoo MD, Westerhof W, Bos JD. Development of guidelines for the treatment of vitiligo. Arch Dermatol 1999; 135: 1514-1521
- Sandra A., Pai S., Shenoi S.D. Unstable vitiligo responding to methotrexate. Indian J. Dermatol. VenereolLeprol. 1998; 64(6):309