5 -10 (72) 2024 - Madjidova Y.N., Inoyatova S.O. - MATRIX METALLOPROTEINASE-9 AND ITS TISSUE INHIBITOR-1 AS A PREDICTOR OF CEREBROVASCULAR PATHOLOGY

MATRIX METALLOPROTEINASE-9 AND ITS TISSUE INHIBITOR-1 AS A PREDICTOR OF CEREBROVASCULAR PATHOLOGY

Madjidova Y.N. - Tashkent State Dental Institute Uzbekistan

Inoyatova S.O. - Tashkent State Dental Institute Uzbekistan

Abduqodirov E.I. - Tashkent State Dental Institute Uzbekistan

Resume

87 patients with cerebrovascular diseases and strokes aged from 50 to 78 years, average age 67.9±4.8 years, were examined. The revealed tendency to increase the level of MMP-9, TIMP-1 and their ratio in the serum in patients with cerebrovascular diseases can be regarded as a predictor of the severity of the cerebrovascular process.

Keywords: matrix metalloproteinase (MMP-9), tissue inhibitor of matrix metalloproteinase (TIMP-1), cerebrovascular diseases.

First page

33

Last page

36

For citation:Madjidova Y.N., Inoyatova S.O., Abduqodirov E.I. - MATRIX METALLOPROTEINASE-9 AND ITS TISSUE INHIBITOR-1 AS A PREDICTOR OF CEREBROVASCULAR PATHOLOGY//New Day in Medicine 10(72)2024 33-36 https://newdayworldmedicine.com/en/new_day_medicine/10-72-2024

List of References

  1. Berejanskaya S.B., Lukyanova E.A., Javoronkova T.E., Kaushanskaya E.Ya., Sozaeva D.I. Qon-miya to'sig'ini tarkibiy va funktsional tashkil etishning zamonaviy kontseptsiyasi va uning qarshiligini buzishning asosiy mexanizmlari. //Pediatriya. 2017;96(1):135-141.
  2. Grigorkevich O.S., Mokrov G.V., Kosova L.Yu. Matritsali metalloproteinazalar va ularning inhibitörleri //Farmakokinetika va farmakodinamika. 2019;2:3-16. DOI: 10.24411/2587-7836-2019-10040.
  3. Konstantinova E.V., Shurdumova M.X. O'tkir fokal miya ishemiyasi patogenezida hujayradan tashqari matritsani yo'q qilish va qayta qurish. //Consilium Medicum. 2015;17(12):50-54.
  4. Markelova E.V., Zdor V.V., Romanchuk A.L. va boshqalar. Matritsali metalloproteinazalar: ularning sitokin tizimi bilan aloqasi, diagnostik va prognostik potentsial //Immunologiya, allergologiya, infektologiya. 2016;2:11-22.
  5. Paltsin A.A. Qon tomirida matritsali proteinazalar //Patologik fiziologiya va eksperimental terapiya. 2017;61(3):110-115.
  6. Reznik E.V., Krupnova E.S., Bilinskaya M.A., Yasnovskaya A.A., Nikitin I.G., Perekov S.N. Surunkali yurak etishmovchiligi bo'lgan bemorlarda matritsali metalloproteinazalar, ularning ingibitorlari va yallig'lanish belgilari. //RMJ. 2023;9:12-17.
  7. Teplyakov A.T., Andriyanova A.V., Pushnikova E. Yu. va boshqalar. Matritsali metalloproteinaz-1 to'qimalarining inhibitori (TIMP-1) surunkali etishmovchilikda ishemik miokardni qayta qurish uchun mustaqil marker sifatida. //Sibir tibbiyot jurnali. 2014;29(2):28-34.
  8. Shadrina A.S., Plieva Ya.Z., Kushlinskiy D.N., Morozov A. A., Filipenko M. L., Chang V.L., Kushlinskiy N.E. Matritsali metalloproteinazalarning tasnifi, faoliyatini tartibga solish, genetik polimorfizmi normal va patologik //Klinik tibbiyot almanaxida. 2017;45(4):266-279. doi: 10.18786/2072-0505-2017-45-4-266-279
  9. Freitas-Rodríguez S., Folgueras A.R., López Otín C. The role of matrix metalloproteinases in aging: Tissue remodeling and beyond. //Biochim Biophys Acta, 2017;0167-4889(17)30118-0. DOI: 10.1016/j.bbamcr.2017.05.007.
  10. Laronha, H. Structure and Function of Human Matrix Metalloproteinases / H. Laronha, J. Caldeira //Cells. 2020;9(5):1076.
  11. Levin M., Udi Y., Solomonov I., Sagi I. Next Generation Matrix Metalloproteinase Inhibitors – Novel Strategies Bring New Prospects. //Biochim Biophys Acta, 2017;0167-4889(17)30161-1. doi: 10.1016/j.bbamcr.2017.06.009.
  12. Van Lint, P. Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation / P. Van Lint, C. Libert //J Leukoc Biol, 2007;82(6):1375-1381

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