Eshonkhodjaeva D.D. - Tashkent State Dental Institute

Muratova N.D. - Tashkent State Dental Institute

Babadjanova G.S. - Tashkent Medical Academy

Resume

Recent years have been characterized by an increase in the frequency of detection of myocarditis in pregnant women after COVID-19 during gestation, which can lead to complications during pregnancy. To determine the characteristics of the course of gestation and childbirth in pregnant women with COVID-19 associated myocarditis, we conducted prospective studies of 145 pregnant women with myocarditis, who were divided: 75 pregnant women who had COVID-19, 46 pregnant women with chronic focal myocarditis, and 24 healthy pregnant women with similar terms of gestation. Immunological studies were carried out to determine the total number of leukocytes and lymphocytes. Conclusions. The clinical picture of COVID-19 associated myocarditis develops mainly 3-4 weeks after COVID-19. Changes in the general immune status in pregnant women of groups 1 and 2 were characterized by an increase in B-lymphocytes by 3 or more times, the level of 3% CEC was 4.8 times higher in patients of group 1 than in group 2 (OR = 4.9, P < 0.001), an increase in the pro-inflammatory cytokine IL-6 in the first group is a characteristic sign of the inflammatory process in the myocardium in COVID-19 associated myocarditis.

Key words: myocarditis in pregnant women, COVID-19 and pregnancy, cytokines, immunoglobulins.

First page

268

Last page

272

For citation:Eshonkhodjaeva D.D., Muratova N.D., Babadjanova G.S. - FEATURES OF THE IMMUNE STATUS IN PREGNANT WOMEN WITH COVID-19 ASSOCIATED MYOCARDITIS//New Day in Medicine 10(72)2024 268-272 https://newdayworldmedicine.com/en/new_day_medicine/10-72-2024

List of References

1. Расмуссен С.А., Смулиан Дж. К., Ледницки Дж. А. и др. Коронавирус заболевание 2019 (COVID-19) и беременность: что нужно знать акушерам. //Am J ObstetGynecol 2020;222(5):415-426.
2. Розыходжаева Г.А., Мардиев А.А., Жураев О.Р., Розыходжаева Ф.А. / Изучение особенностей нагрузочного тестирования в начальном периоде реабилитации после COVID-19 //Кардиология на марше 2021 Ежегодная Всероссийская научно-практическая конференция и 61-я сессия ФГБУ «НМИЦ кардиологии» Минздрава России Кардиологический вестник 2021; Т. 16, спецвыпуск
3. Сергеева В.А., Липатова Т.Е. Миокардит на фоне COVID-19: клинические особенности и медикаментозное лечение //РМЖ. Медиц.обозрение. 2022;6(1). DOI: 10.32364/2587-6821-2022-6-1-26-32.
4. Hu H., Ma F., Wei X., Fang Y. Coronavirus fulminant myocarditis saved with glucocorticoid and human immunoglobulin, available at: https://pubmed.ncbi.nlm.nih.gov/32176300/.
5. Juusela A, Nazir M, Gimovsky M. Two cases of coronavirus 2019-related cardiomyopathy in pregnancy. //Am J Obstet Gynecol MFM. 2020 May;2(2):100113
6. Lippi G., Lavie CJ, Sanchis-Gomar. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis
7. Mehta L.S., Warnes C.C.A., Bradly V.C.E., Burton T., Economy K., Mehran R., Safdar B., Sharma G., Wood M., Valente A.M., Volgman A.S. Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association. //Circulation. 2020;141:e884-e903.
8. Wu DD, Gao L, Huang O, Ullah K, Guo MX, Liu Y, Zhang J, Chen L, Fan JX, Sheng JZ, Lin XH, Huang HF. Increased Adverse Pregnancy Outcomes Associated With Stage 1 Hypertension in a Low-Risk Cohort: Evidence From 47 874 Cases. //Hypertension. 2020 Mar;75(3):772-780.
9. Zeng J.H., Liu Y.X., Yuan J. First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. Infection 2020;48:773-777.

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