• Home
  • NEW DAY MEDICINE
  • 11 (73) 2024
  • 83 -11 (73) 2024 - Navruzova R.S., Kurbanov B.B. - RETROSPECTIVE ANALYSIS OF PREGNANCY AND DELIVERY OUTCOMES IN WOMEN WITH VARIOUS DEGREES OF PREECLAMPSIA

83 -11 (73) 2024 - Navruzova R.S., Kurbanov B.B. - RETROSPECTIVE ANALYSIS OF PREGNANCY AND DELIVERY OUTCOMES IN WOMEN WITH VARIOUS DEGREES OF PREECLAMPSIA

RETROSPECTIVE ANALYSIS OF PREGNANCY AND DELIVERY OUTCOMES IN WOMEN WITH VARIOUS DEGREES OF PREECLAMPSIA

Navruzova R.S. - Tashkent Pediatric Medical Institute

Kurbanov B.B. - Tashkent Pediatric Medical Institute

Kurbanov D.D. - Tashkent Pediatric Medical Institute

Resume

The aim of this work was to conduct a retrospective analysis of pregnancy and childbirth outcomes in women with varying degrees of preeclampsia. Materials and methods: A retrospective analysis of pregnancy and childbirth was conducted in 125 women in the third trimester of pregnancy. Of these, 95 pregnant women with varying degrees of preeclampsia and 30 pregnant women with an uncomplicated gestational period. Results: When studying the obstetric history, it was revealed that 36 (37.9%) women had previous pregnancies that ended in spontaneous abortions before 27 weeks. Preterm births occurred in 23 (24.2%) and 3 (10.0%) women in the control group, respectively (P<0.05). The frequency of miscarriage in previous pregnancies was 50 (52.6%) in the main group and 4 (13.3%) in the control group (P<0.001). Conclusions: All of the above gives us reason to believe that preeclampsia has a special clinical picture and affects pregnancy outcomes.

Key words: Preeclampsia, pregnancy, childbirth

First page

481

Last page

487

For citation:Navruzova R.S., Kurbanov B.B., Kurbanov D.D - RETROSPECTIVE ANALYSIS OF PREGNANCY AND DELIVERY OUTCOMES IN WOMEN WITH VARIOUS DEGREES OF PREECLAMPSIA//New Day in Medicine 11(73)2024 481-487 https://https://newdayworldmedicine.com/en/new_day_medicine/11-73-2024

List of References

  1. Аюпова Ф. М., Хамраев Х. Х., Махмудова С. Э. Молекулярно-генетические факторы преэклампсии и их взаимосвязь с течением и исходами беременности //Журнал Репродуктивного Здоровья и Уро-Нефрологических Исследований. – 2020. – Т. 1. – №. 2.
  2. Ихтиярова Г. А., Негматуллаева М. Н., Туксанова Д. И. Современные аспекты коррекции гемодинамических нарушений у родильниц с преэклампсией легкой степени //Педиатрия (узб). -2003. -Спец. вып. -С. 97-99.
  3. Захидова Н. Э., Хегай Т. Р., Арипова Т. У. Мета-анализ факторов риска развития преэклампсии //Журнал теоретической и клинической медицины. – 2018. – №. 2. – С. 72-76.
  4. Абдурахманова Д. Н., Мадаминова М. Ш., Садуллаева А. Ф. Преэклампсия-актуальная проблема в современном акушерстве //International scientific review. – 2016. – №. 5 (15).
  5. Мирзаева Д. Б. Особенности течения родов у женщин с тяжелой преэклампсией //Вестник Российского государственного медицинского университета. – 2015. – №. 2. – С. 50-51.
  6. Курбанов Б. Б. Морфофункциональные изменения плаценты и их взаимосвязь с уровнем белка Sflt1 в крови беременных с преэклампсиями различной степени //Вестник экстренной медицины. – 2020. – Т. 13. – №. 1-2. – С. 87-91.
  7. Sun Y. et al. Influence of autoantibodies against AT1 receptor and AGTR1 polymorphisms on candesartan-based antihypertensive regimen: results from the study of optimal treatment in hypertensive patients with anti-AT1-receptor autoantibodies trial //Journal of the American Society of Hypertension. – 2014. – Т. 8. – №. 1. – С. 21-27.
  8. Begum R., Begum A., Johanson R. A low dose (“Dhaka”) magnesium sulphate regime for eclampsia //Acta Obstet. Gynecol. Scand. -2001. -Vol.80, №11. -P. 998-1002.
  9. Tejera E. et al. Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis //BMC medical genomics. – 2017. – Т. 10. – №. 1. – С. 1-19.
  10. Wang L. et al. Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia //American journal of obstetrics and gynecology. – 2006. – Т. 195. – №. 1. – С. 162-171.
  11. Soltani-Zangbar M. S. et al. Angiotensin type 2 receptor gene polymorphisms and susceptibility to preeclampsia //Journal of reproduction & infertility. – 2018. – Т. 19. – №. 2. – С. 95.
  12. Srinivas S., Morrison A., Elovitz M. 760: Genetic contribution of the renin-angiotesin system to preeclampsia //American Journal of Obstetrics & Gynecology. – 2009. – Т. 201. – №. 6. – С. S273.
  13. Semianiv M. M. et al. Association of AGTR1 (rs5186), VDR (rs2228570) genes polymorphism with blood pressure elevation in patients with essential arterial hypertension //Journal of Medicine and Life. – 2021. – Т. 14. – №. 6. – С. 782.
  14. Kurbanov B. 138 The role of vascular endothelial growth factor as markers of hypertension induced pregnancy: Angiogenic factors //Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. – 2016. – Т. 6. – №. 3. – С. 248.
  15. Zhao L. Genetics of Preeclampsia: Identifying Risk Variants Using Epidemiological, Computational, and Experimental Methods. – Yale University, 2012.
  16. Belfort M., Varner M. Cerebral perfosion, perfusion pressure and not cerebral blood flow may be the critical determinant of intracranial injury in preeclampcia: a new hypoteses //Am J Obstet Gynec. -2002. –Vol.107. –P. 625-634.
  17. Biasiutti F., Strebel J. Anticoagulation and antiaggregation during pregnancy //Ther Umsch. -2003. -Vol.60, №1. -P. 54-58.
  18. Blood cell lead, calcium, and magnesium levels associated with pregnancy-induced hypertension and preeclampsia /E. B. Davson, D. R. Evans, R. Kelly //Biol. Trace Elem. Res. -2000. -Vol.74, №2. -P. 107-116.
  19. Rahimi Z. et al. Endothelial nitric oxide synthase (eNOS) 4a/b and G894T polymorphisms and susceptibility to preeclampsia //Journal of Reproduction & Infertility. – 2013. – Т. 14. – №. 4. – С. 184.
  20. Kim Y. J. et al. No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations //Twin Research and Human Genetics. – 2008. – Т. 11. – №. 1. – С. 77-83.

    file

    download