154 -11 (73) 2024 - Sh.S. Burxonov, A.I. Iskandarov - ASSESSMENT OF PATHOLOGICAL CHANGES IN MYOCARDIAL TISSUE OF PATIENTS WHO DIED FROM COVID-19 INFECTION

ASSESSMENT OF PATHOLOGICAL CHANGES IN MYOCARDIAL TISSUE OF PATIENTS WHO DIED FROM COVID-19 INFECTION

Sh.S.Burxonov - Republican Scientific and Practical Center for Forensic Medical Examination Ministry of Health Uzbekistan

A.I. Iskandarov - Republican Scientific and Practical Center for Forensic Medical Examination Ministry of Health Uzbekistan

Resume

The new coronovirus infection Sovid-19 pandemic has been a difficult test for the health systems of many countries. Today, the clinical and epidemiological features of the disease are the subject of discussion and have not been sufficiently explored. Research on the effects of the coronavirus on the cardiovascular system deserves special attention. This is of great interest because myocardial injury is the second most common cause of death in Covid-19 [1]. The harmful effect of the virus on the cardiovascular system is explained by multifactoriality. The virus has a direct and indirect effect on its elements. Hypoxic, metabolic and ischemic damage to the myocardium, sometimes petechial and scattered hemorrhages with microangiopathy, small focal, sometimes transmural myocardial infarctions in the case of thrombosis of the heart arteries, presence of virus-like lesions on the walls of coronary arteries due to the absence of atherosclerosis in microscopic examination, that is, the detection of mononuclear infiltration in and around the wall of blood vessels is the basis for saying that it is directly affected by the coronavirus.

Key words: myocardium, cardiomyocyte, microvessels, SARS-CoV-2; COVID-19;

First page

883

Last page

886

For citation:Sh.S. Burxonov, A.I. Iskandarov - ASSESSMENT OF PATHOLOGICAL CHANGES IN MYOCARDIAL TISSUE OF PATIENTS WHO DIED FROM COVID-19 INFECTION//New Day in Medicine 11(73)2024 883-886 https://https://newdayworldmedicine.com/en/new_day_medicine/11-73-2024

List of References

1. Филимонова А. А., Шурпо Е. М., Котляров С. Н., Булгаков А. А. Острые повреждения миокарда при COVID-19: виды, механизмы развития, критерии диагноза, прогноз //Наука молодых (Eruditio Juvenium). 2022;10(3):311-326. https://doi.org/10.23888/HMJ2022103311-326.
2. Забозлаев Ф.Г., Кравченко Э.В., Галлямова А.Р., Летуновский Н.Н. Патологическая анатомия легких при новой коронавирусной инфекции (COVID-19). Предварительный анализ аутопсийных исследований. //Клиническая практика. 2020;11(2):21-37. doi: 10.17816/clinpract34849).
3. Бубнова М.Г., Аронов Д.М. COVID-19 и сердечно-сосудистые заболевания: от эпидемиологии до реабилитации //Пульмонология. 2020;30(5):688-699. doi: 10.18093/0869-01892020-30-5-688-699.
4. Hendren N.S., Drazner M.H., Bozkurt B., et al. Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome //Circulation. 2020;141(23):1903-1914. doi:10.1161/CIRCULATIONAHA.120.047349
5. Tian X, Li C, Huang A, et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. //Emerg Microbes Infect. 2020;9(1):382-385. doi: 10.1080/22221751.2020.1729069.
6. Coronavirus: Novel Coronavirus (COVID-19) Infection. Reviewed by: Perlman S, MD, PhD (Professor Department of Microbiology and 38 Immunology Department of Pediatrics University of Iowa). //Published February 5, 2020; Updated 2020 March 25. Elsevier; 2020;10 p.
7. Исраилов Р.И., Эргашева З. (2022). Морфологические проявления поражения миокарда при COVID-19. //Международный журнал научной педиатрии, 2023;1(1):46-52. https://doi.org/10.56121/2181-2926-2022-1-46-52.

   file

   download