70 -1 (75) 2025 - Zhumaev M.F., Nargiza N.P., Adzhablayeva D.N. - IMMUNOLOGICAL STATUS OF CHILDREN WITH LATENT TUBERCULOSIS INFECTION FROM FOCI OF HOUSEHOLD TUBERCULOSIS

IMMUNOLOGICAL STATUS OF CHILDREN WITH LATENT TUBERCULOSIS INFECTION FROM FOCI OF HOUSEHOLD TUBERCULOSIS

Zhumaev M.F. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Nargiza N.P. - Republican Specialized Scientific and Practical Center of Phthisiology and Pulmonology

Adzhablayeva D.N. - Samarkand State Medical University

Resume

The study is devoted to the study of immunological parameters of children with latent tuberculosis infection (n=122) living in foci of household tuberculosis, upon admission and in dynamics, after 12-24 months. After the end of this period, the presence of active forms of tuberculosis was found in 40 (32.8%) children, they made up the first group of the examination, in 80 children (65.5%) LT did not develop into active tuberculosis, therefore they were assigned to the second group of the examination. In the I group of children, there was an increase in papule size of Diaskintest after 12-24 months, compared with the results of the test performed upon admission to the tuberculosis dispensary. In the II group of children, there was a tendency to decrease the size of the papule as a result of preventive chemotherapy and 12-24 months after its completion. When studying the level of interleukin status in I group of children, there was initially a significant increase in IL-2 levels compared with group II. Interferon status (INF-γ) was decreased (p<0.0001). The INF-γ/IL-2 ratios in both groups were statistically different from each other (66.55±0.25 in I group, 88.58±0.08 in II group). Thus, in a child with latent tuberculosis infection living in the focus of household tuberculosis infection, the tendency to increase cytokine concentration (IL-2) and decrease cytokine concentration (IL-4, IFN-γ) may act as a modifying factor in the implementation of latent tuberculosis infection into active forms of tuberculosis.

Key words: children, latent tuberculosis infection, interleukins, interferons, focus of household tuberculosis

First page

410

Last page

414

For citation:Zhumaev M.F., Nargiza N.P., Adzhablayeva D.N. - IMMUNOLOGICAL STATUS OF CHILDREN WITH LATENT TUBERCULOSIS INFECTION FROM FOCI OF HOUSEHOLD TUBERCULOSIS//New Day in Medicine 1(75)2025 410-414 https://https://newdayworldmedicine.com/en/new_day_medicine/1-75-2025

List of References

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