3 -2 (76) 2025 - Narzullaev N.U. - LOCAL IMMUNE STATUS IN THE INFLAMMATORY PROCESS IN THE UPPER RESPIRATORY TRACT IN PATIENTS INFECTED WITH COVID-19

LOCAL IMMUNE STATUS IN THE INFLAMMATORY PROCESS IN THE UPPER RESPIRATORY TRACT IN PATIENTS INFECTED WITH COVID-19

Narzullaev N.U. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

In the period from 2020-2021, we examined COVID-19 infected 53 patients who applied to the infectious diseases department of the Bukhara Regional Infectious Diseases Medical Center. Of these, 32 people suffered from acute rhinosinusitis and 21 people-acute purulent tonsillitis. All patients underwent a standard examination: clarification of complaints and anamnestic data. Examination of the upper respiratory tract organs was carried out according to the generally accepted scheme. We also studied the indicators of local immunity of the mucous membranes of the upper respiratory tract using immunohistochemical studies with antibodies to T-helper lymphocytes (CD4 +), suppressor T-lymphocytes (CD8 +) and B-lymphocytes (CD20) in patients of different groups. Indicators of local immunity of the mucous membrane of the nasal cavity and pharynx in the first two weeks of the acute process correspond to an adequate response of local immunity to an infectious agent; the third week is characterized by an imbalance of local immune protection, which indicates a high activity of the inflammatory process, which is a milestone in the course of the disease.

Key words: acute rhinosinusitis, acute tonsillitis, T-lymphocytes, B-lymphocytes.

First page

12

Last page

15

For citation:Narzullaev N.U. - LOCAL IMMUNE STATUS IN THE INFLAMMATORY PROCESS IN THE UPPER RESPIRATORY TRACT IN PATIENTS INFECTED WITH COVID-19//New Day in Medicine 2(76)2025 12-15 https://https://newdayworldmedicine.com/en/new_day_medicine/2-75-2025

List of References

1. Aripova T.U., Ismailova A.A. COVID-19: possibilities of immunotherapy :review //Journal of Theoretical and Clinical Medicine: scientific and practical medical journal /Academy of Sciences of the Republic of Uzbekistan. - Tashkent : Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan. 2020;3:8-12.
2. Assanovich M.A. Escitalopram in pharmacotherapy of mental disorders in patients with COVID-19 //Medical news. 2021;1(316):59-62.
3. Bazdyrev E.D. Coronavirus infection - an urgent problem of the XXI century //Complex problems of cardiovascular diseases. 2020;9(2):6-16.
4. Bachilo E.V. Mental health of the population during the COVID-19 pandemic //Journal of Neurology and Psychiatry named after C.C. Korsakov. 2020;120(10):130-136.
5. Bekzhanova O.E., Kayumova V.R., Alimova S.H. Clinical and pathogenetic aspects of olfaction and taste disorders in COVID-19. Tashkent State Dental Institute 2021; 67-74 pp.
6. Belyakov N.A., Rassokhin V.V., Yastrebova E.B. Coronavirus infection COVID-19. the nature of the virus, pathogenesis, clinical manifestations. message 1 //HIV infection and immunosuppression. 2020;12(1):7-21.
7. Lantsov A.A., Khmelnitskaya N.M., Endaltseva E.B. Local immunity and treatment of patients with chronic purulent otitis media //News of otorhinolaryngology and logopathology. 1999;1:3-7.
8. Narzulaev N.U., Khamidova N.K.,Mirzayeva M.R. Clinical and immunological study of the effect of various types of therapy on the course of allergic rhinitis in children with hymenolepidosis //Annals of the Romanian Society of Cell Biology 2021; 1900-1908 pp.
9. Narzullaev N.U.,Mirzayeva M.R. Immunological features of infectious diseases etiology of mononucleosis caused by Epstein-Barr virus in children //International Journal of Pharmaceutical Research 2021; 2667-2671 pp.
10. Narzullaev N.U., Rakhmatov A.A. Cytokine profile in children with acute inflammation of the middle earth on the background of chronic active hepatitis //New day medicine Tashkent 2021;2(34):15-17. https://newdayworldmedicine.com/en/article/203

    file

    download