42 -4 (78) 2025 - Zokirov N.U., Tolibov A.A. - THE ASSOCIATION BETWEEN ATRIAL FIBRILLATION AND SUDDEN CARDIAC DEATH
THE ASSOCIATION BETWEEN ATRIAL FIBRILLATION AND SUDDEN CARDIAC DEATH
Zokirov N.U. - Republican Specialized Scientific and Practical Medical Center of Cardiology Uzbekistan
Tolibov A.A. - Republican Specialized Scientific and Practical Medical Center of Cardiology Uzbekistan
Resume
High-level scientific studies have highlighted the importance of sudden cardiac death (SCD) and atrial fibrillation (AF), including their causes of death and disability. This article examines the relationship between SCD and AF. The article also analyzes their underlying molecular, genetic, and physiological mechanisms, and provides a scientific explanation for the relationship between these conditions. The relationship between SCD and AF is based on the fact that many cardiological studies have identified AF as one of the main causes of SCD. Studies have shown that AF can increase the risk of SCD by causing myocardial remodeling, increasing the risk of infarction, changes in the autonomic nervous system, and other physiological factors. In addition, the article emphasizes the need for timely identification of patients and appropriate preventive measures to prevent the development of SCD. The scientific studies presented in the article indicate the need to develop effective treatment and preventive measures for patients with AF today.
Key words: sudden cardiac death, atrial fibrillation.
First page
250
Last page
256
For citation:Zokirov N.U., Tolibov A.A. - THE ASSOCIATION BETWEEN ATRIAL FIBRILLATION AND SUDDEN CARDIAC DEATH//New Day in Medicine 4(78)2025 250-256 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025
List of References
- Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidbüchel H, Hindricks G, Kautzner J, Kuck KH, Mont L, Ng GA, Rekosz J, Schoen N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns HJGM, Breithardt G; EAST-AFNET 4 Trial Investigators. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med. 2020 Oct 1;383(14):1305-1316. doi: 10.1056/NEJMoa2019422. Epub 2020 Aug 29. PMID: 32865375.
- Бўлмачалар фибрилляцияси бўлган беморларни таш ҳислаш ва даволаш бўйича миллий клиник баённома – Р.Д.Курбонов, Н.У.Закиров, Дж.Б.Ирисов, Ш.Кучкаров - 243-285 Қоринчалар аритмияси бўлган беморларни даволаш ва тўсатдан юрак ўлимининг олдини олиш бўйича миллий клиник баённома – Р.Д.Курбонов, Г.У.Муллабаева, А.Г.Кеворков, Э.Я.Турсунов 389-477
- Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, et al; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137:e67–e492. doi: 10.1161/CIR.0000000000000558.
- Roy D, Brugada P, Wellens HJ. Atrial tachycardia facilitating initiation of ventricular tachycardia. Pacing Clin Electrophysiol. 1983;6:47–52. doi: 10.1111/j.1540-8159.1983.tb06581.x
- Link MS, Bockstall K, Weinstock J, Alsheikh-Ali AA, Semsarian C, Estes NAM 3rd, Spirito P, Haas TS, Rowin EJ, Maron MS, et al. Ventricular tachyarrhythmias in patients with hypertrophic cardiomyopathy and defibrillators: triggers, treatment, and implications. J Cardiovasc Electrophysiol. 2017;28:531–537. doi: 10.1111/jce.13194
- Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, et al; Authors/ Task Force Members. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC)Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015;36:2793–2867. doi: 10.1093/eurheartj/ehv316 6.
- Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, Deal BJ, Dickfeld T, Field ME, Fonarow GC, et al. 2017 AHA/ACC/ HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2018;72:1677–1749. doi: 10.1016/j.jacc.2017.10.053
- Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout JS, Bastarache L, Ramirez AH, Mosley JD, Pulley JM, Basford MA, et al; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) QRS Group. Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation. 2013;127:1377–1385. doi: 10.1161/CIRCULATIONAHA.112.000604
- Oberti C, Wang L, Li L, Dong J, Rao S, Du W, Wang Q. Genomewide linkage scan identifies a novel genetic locus on chromosome 5p13 for neonatal atrial fibrillation associated with sudden death and variable cardiomyopathy. Circulation. 2004;110:3753–3759. doi: 10.1161/01.CIR.0000150333.87176.C7
- Ling LH, Kistler PM, Ellims AH, Iles LM, Lee G, Hughes GL, Kalman JM, Kaye DM, Taylor AJ. Diffuse ventricular fibrosis in atrial fibrillation: noninvasive evaluation and relationships with aging and systolic dysfunction. J Am Coll Cardiol. 2012;60:2402–2408. doi: 10.1016/j.jacc.2012.07.065
- Hsu LF, Jaïs P, Sanders P, Garrigue S, Hocini M, Sacher F, Takahashi Y, Rotter M, Pasquié JL, Scavée C, et al. Catheter ablation for atrial fibrillation in congestive heart failure. N Engl J Med. 2004;351:2373–2383. doi: 10.1056/NEJMoa041018
- Conen D, Chae CU, Glynn RJ, Tedrow UB, Everett BM, Buring JE, Albert CM. Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillation. JAMA. 2011;305:2080–2087. doi: 10.1001/jama.2011.659
- Soliman EZ, Safford MM, Muntner P, Khodneva Y, Dawood FZ, Zakai NA, Thacker EL, Judd S, Howard VJ, Howard G, et al. Atrial fibrillation and the risk of myocardial infarction. JAMA Intern Med. 2014;174:107–114. doi: 10.1001/jamainternmed.2013.11912
- Shibata T, Kawakami S, Noguchi T, Tanaka T, Asaumi Y, Kanaya T, Nagai T, Nakao K, Fujino M, Nagatsuka K, et al. Prevalence, clinical features, and prognosis of acute myocardial infarction attributable to coronary artery embolism. Circulation. 2015;132:241–250. doi: 10.1161/CIRCULATIONAHA.114.015134
- Hou Y, Scherlag BJ, Lin J, Zhang Y, Lu Z, Truong K, Patterson E, Lazzara R, Jackman WM, Po SS. Ganglionated plexi modulate extrinsic cardiac autonomic nerve input: effects on sinus rate, atrioventricular conduction, refractoriness, and inducibility of atrial fibrillation. J Am Coll Cardiol. 2007;50:61–68. doi: 10.1016/j.jacc.2007.02.066
- Roy D, Brugada P, Wellens HJ. Atrial tachycardia facilitating initiation of ventricular tachycardia. Pacing Clin Electrophysiol. 1983;6:47–52. doi: 10.1111/j.1540-8159.1983.tb06581.x
- Link MS, Bockstall K, Weinstock J, Alsheikh-Ali AA, Semsarian C, Estes NAM 3rd, Spirito P, Haas TS, Rowin EJ, Maron MS, et al. Ventricular tachyarrhythmias in patients with hypertrophic cardiomyopathy and defibrillators: triggers, treatment, and implications. J Cardiovasc Electrophysiol. 2017;28:531–537. doi: 10.1111/jce.13194
file
download