• Home
  • NEW DAY MEDICINE
  • 4 (78) 2025
  • 50 -4 (78) 2025 - Abdullayeva U.K., Rakhimova M.B. - APPLICATIONS OF RECTAL SUPPOSITORIES MADE FROM POMEGRANATE SEED OIL FOR ULCERATIVE COLITIS

50 -4 (78) 2025 - Abdullayeva U.K., Rakhimova M.B. - APPLICATIONS OF RECTAL SUPPOSITORIES MADE FROM POMEGRANATE SEED OIL FOR ULCERATIVE COLITIS

APPLICATIONS OF RECTAL SUPPOSITORIES MADE FROM POMEGRANATE SEED OIL FOR ULCERATIVE COLITIS

Abdullayeva U.K. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Rakhimova M.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Pomegranate seed oil consists of a complex set of fatty acids, approximately 80% of which are 18-carbon molecules with three alternating double bonds. In animal experiments, pomegranate seed oil has antioxidant, antitumor, and anti-inflammatory activity. The aim of our study is to increase the effectiveness of the treatment of ulcerative colitis, made in the form of rectal suppositories made from pomegranate seed oil.

Key words: ulcerative colitis, treatment, pomegranate seed oil, rectal suppositories.

First page

301

Last page

305

For citation:Abdullayeva U.K., Rakhimova M.B. - APPLICATIONS OF RECTAL SUPPOSITORIES MADE FROM POMEGRANATE SEED OIL FOR ULCERATIVE COLITIS//New Day in Medicine 4(78)2025 301-305 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

List of References

  1. Hora JJ, Maydew ER, Lansky EP, Dwivedi C. Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J Med Food 2003;6:157-161.
  2. Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci 2004;95:481-486.
  3. Meerts IA, Verspeek-Rip CM, Buskens CA, Keizer HG, Bassaganya-Riera J, Jouni ZE, van Huygevoort AH, van Otterdijk FM, van de Waart EJ. Toxicological evaluation of pomegranate seed oil. Food Chem Toxicol 2009;47:1085–1092.
  4. Mehta R, Lansky EP. Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. Eur J Cancer Prev 2004;13:345–348.
  5. Sassano G, Sanderson P, Franx J, Groot P, van Straalen J, Bassaganya-Riera J. Analysis of pomegranate seed oil for the presence of jacaric acid. J Sci Food Agric 2009;89:1046-1052.
  6. Christine F. C, Chelsea L. S., Camille K. Adkins-Rieck, Josep Bassaganya-Riera, Raquel Hontecillas, Peter Lawrence, J. Thomas Brenna, Zeina E. Jouni, and Bohuslav Dvorak Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing Enterocolitis // Am J Physiol Gastrointest Liver Physiol 303: G744–G751, 2012.
  7. Akisu M, Baka M, Coker I, Kultursay N, Huseyinov A., Ann Nutr Metab 2003;47:262–266.)
  8. Зейналова А. Биологическая активность и терапевтическое действие гранатового масла // Растительные ресурсы. 2019;55(2):151-169.

    file

    download