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222 -4 (78) 2025 - F.M. Sabirov, U.A. Ruzmetov - HISTOLOGICAL FEATURES OF THE THYMUS AND PLACENTA IN NEWBORNS WITH EXTREMELY LOW BIRTH WEIGHT

HISTOLOGICAL FEATURES OF THE THYMUS AND PLACENTA IN NEWBORNS WITH EXTREMELY LOW BIRTH WEIGHT

F.M. Sabirov - Urgench branch of the Tashkent Medical Academy

U.A. Ruzmetov - Urgench branch of the Tashkent Medical Academy

B.S. Yuldashev - Urgench branch of the Tashkent Medical Academy

Resume

Preterm infants with extremely low birth weight (less than 1000 g) belong to a high-risk group for perinatal mortality and complications. Changes in the structure of their placenta and thymus, a central organ of the immune system, are crucial for understanding the pathogenesis of these conditions. Previous studies have noted that placental pathology in newborns with extremely low birth weight is common, especially signs of infection (chorioamnionitis) and impaired maternal circulation are frequently observed. It has also been established that high maternal stress levels or infections can result in reduced thymus size and decreased lymphoid cell count in the fetus. Such histological changes in the placenta and thymus may impact the development of the immune system and clinical conditions of newborns. However, microscopic changes in the placenta and thymus of newborns small for gestational age (for example, 29–35 weeks and weighing less than 1000 g) are insufficiently studied. Therefore, this topic remains relevant, and studying the relationship between pathological processes in the placenta and thymus development is of significant scientific and clinical importance.

Key words: extremely low birth weight, placenta, thymus, gestational period, chorioamnionitis.

First page

1230

Last page

1235

For citation:F.M. Sabirov, U.A. Ruzmetov, B.S. Yuldashev - HISTOLOGICAL FEATURES OF THE THYMUS AND PLACENTA IN NEWBORNS WITH EXTREMELY LOW BIRTH WEIGHT//New Day in Medicine 4(78)2025 1230-1235 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

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