31 -5 (79) 2025 - Djuraeva N.O., Kholov G.A. - THE IMPORTANCE OF CLOTHOPROTEININ THE DEVELOPMENT OF CHRONICKIDNEYDISEASE IN THECONTEXT OF CHRONICHEARTFAILURE

THE IMPORTANCE OF CLOTHOPROTEININ THE DEVELOPMENT OF CHRONICKIDNEYDISEASE IN THECONTEXT OF CHRONICHEARTFAILURE

Djuraeva N.O. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Kholov G.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The review article presents current research data on the importance of the Clotho proteinin the pathogenesis of chronic kidney disease in the context of chronic heart failure. The relationship of the Clotho protein with fibroblast growth factor–23 and its antioxidant properties is presented. It has been describedthat the α–clotho protein reduces the development of endothelial dysfunction and atherosclerosis by reducing oxidative stress and inflammation.

Keywords: Clotho protein, chronic kidney disease, chronic heart failure, antioxidant system, fibroblast–23

First page

150

Last page

153

For citation:Djuraeva N.O., Kholov G.A. - THE IMPORTANCE OF CLOTHOPROTEININ THE DEVELOPMENT OF CHRONICKIDNEYDISEASE IN THECONTEXT OF CHRONICHEARTFAILURE//New Day in Medicine 5(79)2025 150-153 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

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