117 -5 (79) 2025 - O.B. Muminov - IMPROVING PERSONALIZED DIAGNOSIS AND THERAPY OF BRONCHIAL ASTHMA BASED ON THE ASSESSMENT OF ADIPOKINES AND IMMUNOLOGICAL BIOMARKERS

IMPROVING PERSONALIZED DIAGNOSIS AND THERAPY OF BRONCHIAL ASTHMA BASED ON THE ASSESSMENT OF ADIPOKINES AND IMMUNOLOGICAL BIOMARKERS

O.B. Muminov - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This article explores modern aspects of the pathogenesis, diagnosis, and treatment of bronchial asthma (BA), with a focus on the assessment of adipokines (leptin, adiponectin) and immunological biomarkers (IgE, IL-4, IL-5, IL-13). The review includes data from scientific literature, clinical studies, as well as recommendations from GINA and national protocols. An analysis of BA phenotypes is provided; principles of stepwise therapy are discussed, along with emerging classes of drugs (anti-IgE, anti-IL-5). The significance of metabolic and immune dysregulation in the development of severe forms of BA is emphasized

Keywords: bronchial asthma, adipokines, leptin, adiponectin, immunological biomarkers, cytokines, IgE, IL-5, personalized medicine, therapy

First page

579

Last page

582

For citation:O.B. Muminov - IMPROVING PERSONALIZED DIAGNOSIS AND THERAPY OF BRONCHIAL ASTHMA BASED ON THE ASSESSMENT OF ADIPOKINES AND IMMUNOLOGICAL BIOMARKERS//New Day in Medicine 5(79)2025 579-582 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Sánchez-Ortega H. et al. Role of leptin as a link between asthma and obesity: a systematic review and meta-analysis //International Journal of Molecular Sciences. – 2022. – Т. 24. – №. 1. – С. 546.
2. Venkatesan P. 2023 GINA report for asthma //The Lancet Respiratory Medicine. – 2023. – Т. 11. – №. 7. – С. 589.
3. Feshchenko Y. I. et al. Diagnostics and forecasting of non-controlled bronchial asthma //Астма та алергія. – 2018. – №. 3. – С. 24-33.
4. Aringazina R. et al. Pathogenetic role of the microbial agents in the development of immune and allergic inflammation in case of the bronchial asthma. A literature review. – 2022.
5. Ignatov A. et al. Russia in International Institutes in 2022 //Russian Economy in. – 2022. – С. 448.
6. Avdeev S. N. et al. Leukotriene receptor antagonists in the treatment of bronchial asthma: Consensus agreement “Bronchial Asthma and LEukoTriene receptor antagonists (BALET)” //Russian Journal of Allergy. – 2023. – Т. 20. – №. 2. – С. 130-142.

   file

   download