181 -5 (79) 2025 - Gafforova V.F. - CLINICAL, NEUROPHYSIOLOGICAL AND NEUROIMMUNOLOGICAL FEATURES IN CHILDREN WITH FEBRILE SEIZURES

CLINICAL, NEUROPHYSIOLOGICAL AND NEUROIMMUNOLOGICAL FEATURES IN CHILDREN WITH FEBRILE SEIZURES

Gafforova V.F. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Febrile seizures (FS) occur in 2-5% of children under the age of 5 years and are the most common type of acute symptomatic seizures in childhood.60 children were examined, including EEG monitoring and determination of cytokine levels (IL-1b, IL-6, TNF-α). Significant correlations have been established between the severity of convulsive syndrome and the level of pro-inflammatory cytokines. The data obtained emphasize the role of neuroimmune dysregulation and functional immaturity of the central nervous system in the pathogenesis of FS

Keywords: febrile seizures, children, neurophysiology, neuroimmunology, EEG, cytokines, correlation analysis

First page

895

Last page

898

For citation:Gafforova V.F. - CLINICAL, NEUROPHYSIOLOGICAL AND NEUROIMMUNOLOGICAL FEATURES IN CHILDREN WITH FEBRILE SEIZURES//New Day in Medicine 5(79)2025 895-898 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Альмухамбетова Э. Ф. Фебрильные судороги у детей на этапе скорой медицинской помощи // Вестник КазНМУ. 2012. №1. URL: https://cyberleninka.ru/article/n/febrilnye-sudorogi-u-detey-na-etape-skoroy-meditsinskoy-pomoschi (дата обращения: 12.09.2024).
2. Гаффарова В. Ф. и др. Особенности течения фебрильных судорог у детей //modern scientific challenges and trends. – 2020. – С. 69.
3. Кадыров М. А., Камылов Д. Д. Обзор и тактика фебрильных судорог у детей в условиях палаты интенсивной терапии //Экономика и социум. – 2022. – №. 11-2 (102). – С. 430-433.
4. Гинтер Е.К., Степанова Е.А. Нейроиммунология в детской неврологии. — М.: ГЭОТАР-Медиа, 2020.
5. Hauser WA, Annegers JF, Kurland LT. The epidemiology of febrile seizures in children. Epilepsia. 1980;21(1):43–52.
6. Dubé CM et al. Interleukin-1β contributes to the generation of experimental febrile seizures. Ann Neurol. 2005;57(1):152–155.
7. Shinnar S, Glauser TA. Febrile seizures. J Child Neurol. 2002;17(Suppl 1):S44–S52.
8. Vezzani A, Viviani B. Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability. Neuropharmacology. 2015;96(Pt A):70–82.

   file

   download