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  • 8 -6 (80) 2025 - Jarilkasinova G.J., Аkhmedova G.I. - CHARACTERISTICS OF ANEMIA IN CHRONIC HEART FAILURE: ERYTHROPOIETIC ACTIVITY, AND INFLAMMATION MARKERS

8 -6 (80) 2025 - Jarilkasinova G.J., Аkhmedova G.I. - CHARACTERISTICS OF ANEMIA IN CHRONIC HEART FAILURE: ERYTHROPOIETIC ACTIVITY, AND INFLAMMATION MARKERS

CHARACTERISTICS OF ANEMIA IN CHRONIC HEART FAILURE: ERYTHROPOIETIC ACTIVITY, AND INFLAMMATION MARKERS

Jarilkasinova G.J. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Аkhmedova G.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Aim. To determine the characteristics of erythrocyte parameters, iron metabolism, erythropoiesis, and inflammation markers in patients with chronic heart failure (CHF) and anemia. Material and Methods. The study included 72 patients diagnosed with CHF to describe anemia characteristics (general group). Patients were divided into three subgroups based on serum ferritin (SF) and transferrin saturation (TS) levels. Results. Anemia in CHF is not always associated with iron deficiency (ID) but is characterized by inadequate erythropoietin production, increased C-reactive protein and hepcidin levels. The general group was categorized as follows: absolute ID (42%), functional ID (21%), and non-ID anemia (37%). Conclusion. In the general group of CHF patients, anemia is normochromic and normocytic, characterized by high levels of C-reactive protein, hepcidin, and inadequate erythropoietin production. Patients with absolute and functional ID do not differ significantly in iron metabolism parameters and collectively account for 64% (p=0.01). These two subgroups require iron supplementation at further stages.

Keywords: chronic heart failure, anemia, iron deficiency syndromes, ferritin, erythropoietin, hepcidin.

First page

39

Last page

43

For citation:Jarilkasinova G.J., Аkhmedova G.I. - CHARACTERISTICS OF ANEMIA IN CHRONIC HEART FAILURE: ERYTHROPOIETIC ACTIVITY, AND INFLAMMATION MARKERST//New Day in Medicine 6(80)2025 39-43 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

  1. Rizzo C, Carbonara R, Ruggieri R, et al. Iron deficiency: a new target for patients with heart failure. Front Cardiovasc Med. 2021;908. doi:10.3389/fcvm.2021.709872.
  2. Zahidova KK. Selection of Optimal Therapy at Correction of the Anemic Syndrome in Patients with Chronic Heart Failure. Kardiologiia. 2018;1:25-31. (In Russ.) Захидова К. Х. Выбор оптимальной терапии при коррекции анемического синдрома у больных с хронической сердечной недостаточностью. Кардиология. 2018;1:25-31. doi:10.18087/cardio.2018.1.10076.
  3. Tkachenko EI, Borovkova NY, Buyanova MV. Anemia in chronic heart failure: a look at the pathogenesis and ways of correction. Doctor.Ru. 2019;2(157):31-6. (In Russ.) Ткаченко E. И., Боровкова Н. Ю., Буянова М. В. Анемия при хронической сердечной недостаточности: взгляд на патогенез и пути коррекции. Доктор.Ру. 2019;2(157):31-6. doi:10.31550/1727-23782019-157-2-31-36.
  4. Anand IS, Gupta P. (Anemia and iron deficiency in heart failure: current concepts and emerging therapies. Circulation. 2018;138(1):80-98. doi:10.1161/CIRCULATIONAHA.118.030099.
  5. Vatutin, NT, Taradin GG, Kanisheva IV, et al. Anaemia and iron deficiency in chronic heart failure patients. Kardiologiia. 2019;59(4S):4-20. (In Russ.) Ватутин Н. Т., Тарадин Г. Г., Канишева И. В. и др. Анемии у больных с хронической сердечной недостаточностью. Кардиология. 2019;59(4S):4-20. doi:10.18087/cardio.2638.
  6. Silverberg DS, Dov W, Schwartz D. Is correction of iron deficiency a new addition to the treatment of the heart failure? Int J Mol Sci. 2015;16(6):14056-74. doi:10.3390/ijms160614056.
  7. Ezekowitz JA, O’Meara E, McDonald MA, et al. 2017 Comprehensive update of the Canadian Cardiovascular Society guidelines for the management of heart failure. Can Cardiol. 2017;33(11):1342-433. doi:10.1016/j.cjca.2017.08.022.
  8. Stuklov NI. Iron deficiency and anemia in patients with chronic heart failure. Rational Pharmacotherapy in Cardiology2017;13(5):651-60. (In Russ.) Стуклов Н. И. Дефицит железа и анемия у больных хронической сердечной недостаточностью. Рациональная Фармакотерапия в Кардиологии. 2017;13(5):651-60. doi:10.20996/1819-6446-2017-13-5-651-660.
  9. Rukavitsyn OA. Anemia. 2nd ed., revised. and additional. M.: GEOTAR-Media, 2016. 250 р. (In Russ.) Рукавицын О. А. Анемии. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2016. 250 с. ISBN:978-5-9704-4475-7.
  10. Pozzo J, Fournier P, Delmas C, et al. Absolute iron deficiency without anaemia in patients with chronic systolic heart failure is associated with poorer functional capacity.Arch Cardiovasc Dis. 2017;110(2):99-105. doi:10.1016/j.acvd.2016.06.003
  11. Veldhuisen DJ, Ponikowski P, van der Meer P, et al. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation. 2017;136(15):1374-83. doi:10.1161/CIRCULATIONAHA.117.027497.

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