74 -6 (80) 2025 - Khodieva O.I. - FUNCTIONAL EVALUATION USING PH-IMPEDANCE AND MANOMETRY IN REFRACTORY GASTROESOPHAGEAL REFLUX DISEASE

FUNCTIONAL EVALUATION USING PH-IMPEDANCE AND MANOMETRY IN REFRACTORY GASTROESOPHAGEAL REFLUX DISEASE

Khodieva O.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Refractory gastroesophageal reflux disease (GERD) poses a diagnostic and therapeutic challenge despite optimal proton pump inhibitor (PPI) therapy. This article explores the role of esophageal pH-impedance monitoring and high-resolution manometry (HRM) in evaluating pathophysiological mechanisms underlying PPI-resistant GERD. Our findings, based on a cohort of patients with persistent symptoms, emphasize the importance of identifying non-acidic reflux, ineffective esophageal motility, and functional disorders. Accurate interpretation of these functional parameters allows for individualized therapy and avoidance of unnecessary surgical or pharmacologic interventions.

Keywords refractory GERD, pH-impedance, esophageal manometry, weakly acidic reflux, motility disorders, PPI resistance

First page

366

Last page

368

For citation:Khodieva O.I. - FUNCTIONAL EVALUATION USING PH-IMPEDANCE AND MANOMETRY IN REFRACTORY GASTROESOPHAGEAL REFLUX DISEASE//New Day in Medicine 6(80)2025 366-368 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

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