313 -5 (79) 2025 - Ismalova G.K., Oripov R.A. - ASSOCIATION OF VITILIGO WITH OTHER AUTOIMMUNE DISEASES: A CLINICAL AND EPIDEMIOLOGIC STUDY

ASSOCIATION OF VITILIGO WITH OTHER AUTOIMMUNE DISEASES: A CLINICAL AND EPIDEMIOLOGIC STUDY

Ismalova G.K. - Samarkand state Siob мedical College, Uzbekistan, Samarkand

Oripov R.A. - Samarkand State Medical University

Resume

Vitiligo is a chronic skin disease characterized by focal or generalized depigmentation associated with melanocyte destruction. Current research suggests that vitiligo is autoimmune in nature and may be associated with other systemic autoimmune diseases. The aim of the present clinical and epidemiologic study was to determine the prevalence of associated autoimmune diseases among vitiligo patients and to analyze their clinical features. 108 patients with vitiligo who underwent a comprehensive clinical and laboratory examination were included in the study. It was found that 41.7% of patients had concomitant autoimmune pathologies, among which autoimmune thyroiditis, focal alopecia and type 1 diabetes mellitus prevailed. These findings emphasize the need for a multidisciplinary approach to the diagnosis and treatment of vitiligo with mandatory screening for other autoimmune processes

Keywords: Vitiligo, autoimmune diseases, autoimmune thyroiditis, epidemiology, associations, skin

First page

1573

Last page

1577

For citation:Ismalova G.K., Oripov R.A. - ASSOCIATION OF VITILIGO WITH OTHER AUTOIMMUNE DISEASES: A CLINICAL AND EPIDEMIOLOGIC STUDY//New Day in Medicine 5(79)2025 1573-1577 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Taïeb A., Picardo M. Clinical practice. Vitiligo. N Engl J Med. 2009;360(2):160–169.
2. Alikhan A., Felsten L.M., Daly M., Petronic-Rosic V. Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011;65(3):473–491.
3. Spritz R.A. The genetics of generalized vitiligo and associated autoimmune diseases. J Dermatol Sci. 2006;41(1):3–10.
4. Jin Y., Birlea S.A., Fain P.R., Gowan K., Riccardi S.L., Holland P.J., et al. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med. 2010;362(18):1686–1697.
5. Glassman S.J. Vitiligo, reactive oxygen species and T-cells. Clin Sci (Lond). 2011;120(3):99–120.
6. Gill L., Zarbo A., Isedeh P., Jacobsen G., Lim H.W., Hamzavi I. Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study. J Am Acad Dermatol. 2016;74(2):295–302.
7. Arican O., Kurutas E.B. Oxidative stress in the blood of patients with active localized vitiligo. Acta Dermatovenerol Alp Pannonica Adriat. 2008;17(1):12–16.

   file

   download