137 -6 (80) 2025 - Burxanov J.J. - MOLECULAR GENETIC MECHANISMS AND CLINICAL SIGNIFICANCE OF SCAR FORMATION AFTER ABDOMINOPLASTYASTY

MOLECULAR GENETIC MECHANISMS AND CLINICAL SIGNIFICANCE OF SCAR FORMATION AFTER ABDOMINOPLASTYASTY

Burxanov J.J. - University of Business and Sciences of the University of Uzbekistan

Resume

Abdominoplasty is one of the most frequently used operations in modern aesthetic surgery, with more than 900,000 operations performed worldwide each year. Scarring is considered one of the most important complications of surgery, with 15-30% of patients developing hypertrophic or keloid scars. The results of the study revealed three stages of scar formation: inflammation (0-3 days), proliferation (3-21 days) and remodeling (from 21 days to 2 years). Certain molecular factors are involved in each stage: PDGF, TGF-β, VEGF growth factors, MiR-21, mir-29, mir-200 microRNAs, and MMP/TIMP enzymes. Genetic predisposition plays an important role, since the HLA-DRB1*15 allele increases the risk of developing keloids by 2.5 times. With abdominoplasty with a scar length of 30-45 cm, the risk of hypertrophic scar increases dramatically when the stress on the suture line exceeds 15 N/cm2. A decrease in microcirculation by 40-60% and the development of lymphostasis worsen scarring. The results indicate the need for preoperative genetic screening, the development of individual treatment protocols and the use of preventive measures

Keywords: abdominoplasty, scarring, wound healing, collagen synthesis, matrix metalloproteinases, inflammation, fibroblasts, microcirculation, keloid, genophenotype, microRNA, HLA-antigens, prevention

First page

695

Last page

700

For citation:Burxanov J.J. - MOLECULAR GENETIC MECHANISMS AND CLINICAL SIGNIFICANCE OF SCAR FORMATION AFTER ABDOMINOPLASTYASTY//New Day in Medicine 6(80)2025 695-700 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

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