173 -6 (80) 2025 - Sunnatova G.I., Ishankulova D.K. - DIAGNOSTICS OF LOCAL DEFENSE SYSTEM IMPAIRMENTS AND APPROACHES TO THEIR CORRECTION IN CHRONIC LUNG DISEASES

DIAGNOSTICS OF LOCAL DEFENSE SYSTEM IMPAIRMENTS AND APPROACHES TO THEIR CORRECTION IN CHRONIC LUNG DISEASES

Sunnatova G.I. - Samarkand State Medical University

Ishankulova D.K. - Samarkand State Medical University

Resume

The article addresses modern approaches to the diagnosis of disturbances in the local defense system (LDS) of the respiratory tract in patients with chronic lung diseases (CLD). A multi-stage diagnostic algorithm is presented, encompassing the evaluation of anamnesis data, clinical and laboratory indicators, formulation of assumptions regarding the nature of LDS defects, and their confirmation through immunological and functional tests. It is noted that the application of this approach makes it possible to identify LDS impairments in 57.2% of CLD patients. The paper describes methods for correcting identified defects, including the use of levamisole to stimulate phagocytic activity and the T-cell immune component, intermittent plasmapheresis in steroid-dependent bronchial asthma, administration of pyrogenal and immunoglobulins in immunodeficiencies, as well as lysozyme inhalations to improve mucociliary clearance. The implementation of these comprehensive immunocorrective strategies contributes to reducing the frequency and severity of exacerbations, lowering the need for steroids and antibacterial agents, and achieving a stable therapeutic and preventive effect in patients with CLD.

Keywords: immunocorrection; immunodeficiency; immunoglobulins; levamisole; local defense system; lysozyme inhalations; mucociliary clearance; plasmapheresis; pyrogenal; rehabilitation pulmonology.

First page

890

Last page

893

For citation:Sunnatova G.I., Ishankulova D.K. - DIAGNOSTICS OF LOCAL DEFENSE SYSTEM IMPAIRMENTS AND APPROACHES TO THEIR CORRECTION IN CHRONIC LUNG DISEASES//New Day in Medicine 6(80)2025 890-893 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

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