• Home
  • NEW DAY MEDICINE
  • 7 (81) 2025
  • 38 -7 (81) 2025 - Shayeva R.G., Shomurodov K.E. - EPITHELIALISATION OF THE PALATE AFTER USING A COLLAGEN PILLOW: CLINICAL AND CYTOLOGICAL ANALYSIS

38 -7 (81) 2025 - Shayeva R.G., Shomurodov K.E. - EPITHELIALISATION OF THE PALATE AFTER USING A COLLAGEN PILLOW: CLINICAL AND CYTOLOGICAL ANALYSIS

EPITHELIALISATION OF THE PALATE AFTER USING A COLLAGEN PILLOW: CLINICAL AND CYTOLOGICAL ANALYSIS

Shayeva R.G. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Shomurodov K.E. - Tashkent State Medical University

Resume

The aim of the study is to evaluate the effect of a resorbable collagen pad (CP) on the rate and quality of epithelialization of postoperative palatal wounds using clinical and cytological indices. Material and methods. The study included 100 patients after uranoplasty, randomized into 3 groups. The epithelialization time, pain syndrome (VAS), voice nasalness index and cytological markers (mitotic index, superficial/intermediate layer cell ratio, neutrophil and macrophage count) were assessed on days 3, 7, 14 and 30. Results. KP provided significantly faster complete epithelialization (13.2±1.7 days) versus 16.8±2.1 days (comparative, p<0.01) and 19.4±2.3 days (control, p<0.001). Conclusion. The use of KP significantly improves the rate and morphological quality of palate epithelialization, reducing postoperative rehabilitation

Keywords: uranoplasty, collagen pad, epithelialization, cytology, oral surgery, clinical trial

First page

191

Last page

194

For citation:Shayeva R.G., Shomurodov K.E. - EPITHELIALISATION OF THE PALATE AFTER USING A COLLAGEN PILLOW: CLINICAL AND CYTOLOGICAL ANALYSIS//New Day in Medicine 7(81)2025 191-194 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

List of References

  1. Frolova I.V. et al. Assessment of epithelialization in postoperative palatal defects using cytological criteria. Ross Stomatol Zh. 2020;124(2):45–50.
  2. Grandoch A. et al. Evaluation of resorbable collagen materials for intraoral wound management. J Biomed Mater Res B. 2016;104(4):713–720.
  3. Gutt C. et al. Influence of collagen-based dressings on wound healing in the oral cavity. J Craniomaxillofac Surg. 2021;49(6):427–433.
  4. Huang Y.C., Chai J.Y. Buccal fat pad grafting versus collagen matrix for palatal defects: comparative study. Int J Oral Maxillofac Surg. 2023;52(1):85‑92.
  5. Jedrusik-Pinkas G. Cytological monitoring of palatal wound healing. J Oral Pathol Med. 2022;51:543‑550.
  6. Lee C.H. et al. Biologic wound matrices in cleft palate surgery. Plast Reconstr Surg. 2019;143(3):823–831.
  7. Narang R. et al. Collagen matrices as scaffolds in oral wound healing: A systematic review. Clin Oral Investig. 2024;28:1527‑1538.
  8. Schär M.O. et al. Collagen matrices in tissue regeneration: current applications and future perspectives. Eur Cell Mater. 2018;35:1–23.
  9. Steinhardt Y. et al. Comparative efficacy of collagen and xenograft in intraoral healing. J Clin Periodontol. 2017;44(10):984–993.
  10. Stupp Y. et al. Effects of collagen-based scaffolds on keratinocyte migration. Tissue Eng Part A. 2015;21(1-2):188–198.

    file

    download