61 -7 (81) 2025 - Yarmatova Sh.Z., Ikhtiyarova G.A. - CLINICAL, ANAMNESTIC, LABORATORY AND INSTRUMENTAL PARAMETERS IN WOMEN WITH FETAL NON-PREGNANCY

CLINICAL, ANAMNESTIC, LABORATORY AND INSTRUMENTAL PARAMETERS IN WOMEN WITH FETAL NON-PREGNANCY

Yarmatova Sh.Z. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Ikhtiyarova G.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Navruzova N.O. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Objective: To evaluate clinical, anamnestic, laboratory, and instrumental indicators in women with a risk of miscarriage. Materials and Methods: This study included 117 women in their first trimester of pregnancy from Bukhara and Karshi, all experiencing a threat of miscarriage. The participants were divided into three groups: Group 1 — 51 women with a risk of miscarriage after in vitro fertilization (IVF); Group 2 — 46 women with pregnancies up to 14 weeks after unsuccessful IVF attempts; Group 3 (control group) — 20 women with physiologically normal pregnancies. Results: The average age of patients was: Group 1: 23.61±0.46 years; Group 2: 28.17±0.8 years; Group 3: 28.25±0.75 years. Among the 90 patients in the main group, the most common cause of infertility was the tubal factor (39 women, 43.3%). Anovulation was diagnosed in 31 women (34.4%), and idiopathic infertility in 20 women (22.2%). These findings emphasize the importance of a comprehensive and multidisciplinary approach to diagnosing and treating infertility. Even with physiologically progressing pregnancies, there is a risk of bleeding and thrombosis, which is associated with impaired fibrinolytic activity, hypercoagulation, endothelial dysfunction, and changes in blood rheology. When combined with thrombophilia, these factors often lead to complications in IVF pregnancies. Conclusion: Identified changes in the hemostasis system in the main group indicate a hypercoagulable state. This requires careful monitoring during IVF procedures, as a high risk of thrombosis can complicate treatment and reduce its effectiveness

Keywords: In vitro fertilization, miscarriage, ultrasound, hemostasis, hypercoagulation

First page

312

Last page

318

For citation:Yarmatova Sh.Z., Ikhtiyarova G.A., Navruzova N.O. - CLINICAL, ANAMNESTIC, LABORATORY AND INSTRUMENTAL PARAMETERS IN WOMEN WITH FETAL NON-PREGNANCY//New Day in Medicine 7(81)2025 312-318 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

List of References

1. WHO. Miscarriage: Facts and Statistics. World Health Organization. 2022.
2. Kutteh WH. Immunologic aspects of recurrent pregnancy loss. Clinical Obstetrics and Gynecology. 2015;58(3):517-529.
3. Carp H. Recurrent pregnancy loss: causes, controversies, and treatment. Taylor & Francis, 2014.
4. Brenner B. Haemostatic changes in pregnancy. Thrombosis Research. 2014;114(5-6):409-414.
5. Robertson L, Wu O, Langhorne P, et al. Thrombophilia in pregnancy: a systematic review. BJOG. 2016;113(5): 560–570.
6. Martinelli I, et al. Thrombophilia and pregnancy complications. Haematologica. 2013;88(6):624-629.
7. Hellgren M. Hemostasis during normal pregnancy and puerperium. Seminars in Thrombosis and Hemostasis. 2023;29(2):125-130.
8. Di Nisio M, et al. D-dimer test in pregnancy: a systematic review. Journal of Thrombosis and Haemostasis. 2017;5(5): 1113–1118.
9. Clark P, Brennand J. Antenatal screening for thrombophilia in pregnancy. Current Opinion in Obstetrics and Gynecology. 2009;21(2):128-133.
10. Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss. Fertility and Sterility. 2012;98(5):1103-1111.

    file

    download