44 -9 (83) 2025 - Ergasheva M.N., Aliyeva N.R. - DIAGNOSTIC CRITERIA FOR SYSTEMIC INFLAMMATORY RESPONSE IN INFANTS IN THE FIRST YEAR OF LIFE: SUBJECTIVE AND OBJECTIVE ASPECTS

DIAGNOSTIC CRITERIA FOR SYSTEMIC INFLAMMATORY RESPONSE IN INFANTS IN THE FIRST YEAR OF LIFE: SUBJECTIVE AND OBJECTIVE ASPECTS

Ergasheva M.N. - Tashkent State Medical University

Aliyeva N.R. - Tashkent State Medical University

Resume

Systemic inflammatory response syndrome (SIRS) is a systemic inflammatory reaction to various severe damaging factors of infectious and non-infectious origin. SIRS is characterized by increased production of primarily proinflammatory and, to a lesser extent, anti-inflammatory cytokines by virtually all cells of the human body, primarily immunocompetent cells. This pattern of SIRS mediated response to a stimulus is referred to as SIRS with a predominantly proinflammatory mediated response. The most severe and least manageable type is a mixed antagonistic reaction, or dysregulation.

Keywords: systemic inflammatory response, pneumonia, tachycardia, sepsis, fever, allergic diathesis.

First page

269

Last page

272

For citation:Ergasheva M.N., Aliyeva N.R. - DIAGNOSTIC CRITERIA FOR SYSTEMIC INFLAMMATORY RESPONSE IN INFANTS IN THE FIRST YEAR OF LIFE: SUBJECTIVE AND OBJECTIVE ASPECTS//New Day in Medicine 9(83)2025 269-272 https://newdayworldmedicine.com/en/new_day_medicine/9-83-2025

List of References

1. Radzyukevich, Y.V.; Kosyakova, N.I.; Prokhorenko, I.R. Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation. J. Immunol. Res. 2021, 2021, 1762584.
2. Tinoco-Sánchez, M.; Suárez-Cuenca, J.A.; Rubio-Guerra, A.F. Usefulness of eosinopenia as prognostic marker of severity in sepsis. // Med. Interna Mex. 2017;33:572-579.
3. Anand D.; Ray S.; Bhargava S.; Srivastava L.M.; Garg A.; Gafoor, I.; Singh, R.; Dhar, D. Exploration of eosinopenia as a diagnostic parameter to differentiate sepsis from systemic inflammatory response syndrome: Results from an observational study. // Indian J. Crit. Care Med. 2016;20:285-290.
4. Gao, L.; Shi, Q.; Li, H.; Guo, Q.; Yan, J.; Zhou, L. Prognostic value of the combined variability of mean platelet volume and neutrophil percentage for short-term clinical outcomes of sepsis patients. // Postgrad. Med. 2021;133:604-612.
5. Ferreira da Mota, N.V.; Brunialti, M.; Santos, S.S.; Machado, F.R.; Assuncao, M.; Azevedo, L.; Salomao, R. Immunophenotyping of Monocytes During Human Sepsis Shows Impairment in Antigen Presentation: A Shift Toward Nonclassical Differentiation and Upregulation of FCγRi-Receptor. Shock 2020;50:293–300.
6. Radzyukevich, Y.V.; Kosyakova, N.I.; Prokhorenko, I.R. Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation. // J. Immunol. Res. 2021; 1762584.
7. Hohlstein, P.; Gussen, H.; Bartneck, M.; Warzecha, K.T.; Roderburg, C.; Buendgens, L.; Trautwein, C.; Koch, A.; Tacke, F. Prognostic Relevance of Altered Lymphocyte Subpopulations in Critical Illness and Sepsis. // J. Clin. Med. 2019;8:353.
8. Sheikh Motahar Vahedi, H.; Bagheri, A.; Jahanshir, A.; Seyedhosseini, J.; Vahidi, E. Association of Lymphopenia with Short Term Outcomes of Sepsis Patients; A Brief Report. Arch. Acad. Emerg. Med. 2019;7:e14.
9. Pyo, J.Y.; Ha, Y.J.; Song, J.J.; Park, Y.B.; Lee, S.K.; Lee, S.W. Delta neutrophil index contributes to the differential diagnosis between acute gout attack and cellulitis within 24 hours after hospitalization. // Rheumatology 2017;56:795-801.
10. Brady, J.; Horie, S.; Laffey, J.G. Role of the adaptive immune response in sepsis. // Intensive Care Med. Exp. 2020;8:20.

    file

    download