26 -10 (84) 2025 - Аkhtamоv А., Radjabov A. - INFLUENCE OF VARIOUS ENVIRONMENTAL FACTORS ON THE MORPHOFUNCTIONAL STATE OF THE PANCREAS

INFLUENCE OF VARIOUS ENVIRONMENTAL FACTORS ON THE MORPHOFUNCTIONAL STATE OF THE PANCREAS

Аkhtamоv А. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Radjabov A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The morphology and function of the pancreas can be altered by environmental factors such as thermal stress, hypothermia, radiation, electromagnetic fields, and chemical pollution. These factors disrupt the cytological and histological structure of acinar and islet Langerhans cells, triggering inflammation, apoptosis, and fibrosis. Modern morphological and molecular methods allow us to identify changes in pancreatic tissue caused by external factors. These studies are important for maintaining the morphological function of the gland and preventing disease.

Key words: pancreas, islet of Langerhans, morphology, inflammation, fibrosis

First page

144

Last page

147

For citation:Аkhtamоv А., Radjabov A. - INFLUENCE OF VARIOUS ENVIRONMENTAL FACTORS ON THE MORPHOFUNCTIONAL STATE OF THE PANCREAS//New Day in Medicine 10(84)2025 144-147 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

List of References

1. Chen S., Wu X., Li Z. Gamma radiation and apoptosis in pancreatic islets. // Apoptosis. 2019;24(8-9):675–686.
2. Garcia M., Lopez R., Fernandez P. Pesticides effects on pancreatic cell metabolism. // Toxicology Reports. 2020;7:112–121.
3. Huang L., Zhang J., Wang H. Air pollution and pancreatic inflammation risk. // Environmental Research. 2020;189:109913.
4. Ivanov P., Petrov A., Sidorov V. Pancreatic fibrosis induced by heavy metals. // Pathology Journal. 2017;33(2):112–119.
5. Jones M., Brown K. UV radiation and oxidative stress in pancreatic tissues. // Photodermatology Journal. 2022;12(1):17–26.
6. Kim Y., Lee J., Park H. Magnetic field effects on pancreas function. // Bioelectromagnetics. 2019;40(4):251–260.
7. Kolesnikov A., Smirnova T., Ivanova V. Chronic exposure to industrial pollutants and pancreatic fibrosis. // Toxicology and Pathology. 2022;50(1):56–64.
8. Kumar A., Singh B., Patel R. Mitochondrial dysfunction in heat-stressed pancreatic cells. // Cellular Physiology. 2020;235(3):1982–1991.
9. Lee D., Park S. Ion flux imbalance in pancreas under magnetic fields. // Bio electromagnetics. 2018;39(5):371–380.
10. Lee S., Kim D., Park J. Chemical pollutants and pancreatic fibrosis. // Environmental Health Perspectives. 2021;129(5):056001.
11. Lopez M., Sanchez R., Fernandez A. UV-induced oxidative damage in pancreas. // Photobiology Journal. 2023;19(2):98–107.
12. Martinez R., Gomez F., Hernandez L. Gene expression changes induced by pesticides in pancreas. // Toxicogenomics. 2021;15(3):45–53.
13. Martinez R., Hernandez L., Gomez F. Radiation-induced pancreatic structural changes. International Journal of Radiation Biology. 2018;94(9):792–800.
14. Nguyen T., Tran P., Le Q. Heavy metals and oxidative damage in pancreas. Toxicology Letters. 2019;312:59–67.
15. Novikova A., Belov M. Morphological changes of Langerhans islets under chronic toxic exposure. // Russian Journal of Morphology. 2021;31(4):121–130.
16. Peterson M., Clark G. Effects of household chemicals on pancreatic secretion. // Journal of Toxicology. 2021;39(7):678–685.
17. Peterson M., Johnson K., Clark G. Lipid peroxidation in pancreas by water contaminants. // Environmental Toxicology. 2019;34(4):453–461.
18. Petrov A., Sidorov V. Hypothermia-induced pancreatic vascular damage. // Russian Journal of Morphology. 2018;28(3):89–97.
19. Smith J., Johnson R., Brown T. Thermal stress and pancreatic morphology: a review. // Journal of Pancreatic Research. 2019;45(2):123–134.
20. Sokolova N., Ivanov D., Petrov A. Heavy metal toxicity in pancreatic morphology. // Environmental Toxicology. 2017;9(4):199–208.

    file

    download