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  • 56 -10 (84) 2025 - Karimova N.N., Kilicheva B.A. - HORMONAL AND BIOCHEMICAL PROFILE OF FOLLICULAR FLUID AS A MARKER OF OOCYTE QUALITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

56 -10 (84) 2025 - Karimova N.N., Kilicheva B.A. - HORMONAL AND BIOCHEMICAL PROFILE OF FOLLICULAR FLUID AS A MARKER OF OOCYTE QUALITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

HORMONAL AND BIOCHEMICAL PROFILE OF FOLLICULAR FLUID AS A MARKER OF OOCYTE QUALITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Karimova N.N. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Kilicheva B.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age, often associated with anovulation and infertility. This study aimed to analyze the hormonal and biochemical composition of follicular fluid in women with PCOS and to identify correlations between these parameters and oocyte quality during in vitro fertilization (IVF) procedures. The findings demonstrated increased levels of Anti-Müllerian Hormone (AMH), testosterone, and malondialdehyde (MDA)—a marker of oxidative stress—in PCOS patients, along with decreased antioxidant activity (AOA). These alterations were correlated with reduced morphological quality of oocytes and lower fertilization success rates. The parameters of follicular fluid may serve as prognostic biomarkers for IVF outcomes in women with PCOS.

Keywords: PCOS, follicular fluid, AMH, MDA, antioxidant activity, oocyte quality, IVF.

First page

310

Last page

312

For citation:Karimova N.N., Kilicheva B.A. - HORMONAL AND BIOCHEMICAL PROFILE OF FOLLICULAR FLUID AS A MARKER OF OOCYTE QUALITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME//New Day in Medicine 10(84)2025 310-312 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

List of References

  1. Moreira M.V. et al. Follicular fluid composition and reproductive outcomes of women with PCOS undergoing IVF. Reviews in Endocrine and Metabolic Disorders, 2023.
  2. Vale-Fernandes E. et al. Anti-Müllerian hormone as a surrogate of follicular fluid oxidative stress. Frontiers in Endocrinology, 2024.
  3. Yin Q. et al. Proteomic analysis of human follicular fluid in hyperandrogenic PCOS patients. Frontiers in Endocrinology, 2025.
  4. Pan Y. et al. Unraveling the complexity of follicular fluid. Journal of Ovarian Research, 2024.
  5. Chen Y. et al. The impact of follicular fluid oxidative stress on assisted reproduction. Antioxidants (MDPI), 2023.

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