74 -10 (84) 2025 - Kuziyev D.V. - IMMUNOLOGICHESKAYA ROL' IL-10 I FNO-a PRI OSLOZHNENNOM VNEBOL'NICHNOM TONIZE U DETEY DO 1 GODA

IMMUNOLOGICHESKAYA ROL' IL-10 I FNO-a PRI OSLOZHNENNOM VNEBOL'NICHNOM TONIZE U DETEY DO 1 GODA

Kuziyev D.V. - Andijan State Medical Institute

Resume

This article presents the results of a study aimed at evaluating the immunological role of interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) in community-acquired complicated tonsillitis in children under 1 year of age. SSI is a severe respiratory infection that can be associated with high morbidity and mortality in young children. Uncontrolled inflammation is a crucial factor in the severity of the disease and the development of complications. This study identified quantitative changes in the blood levels of IL-10 and TNF-α in complicated and uncomplicated pharyngitis. According to the results obtained, the level of TNF-α was significantly higher in complicated pharyngitis, which indicated inflammatory activity; at the same time, a decrease in the level of IL-10 indicated the ineffectiveness of anti-inflammatory mechanisms. This is explained by a violation of the regulatory balance in the immune system. The results of this study are of great importance for understanding the mechanisms of severe pharyngitis development and serve as a scientific basis for the development of therapeutic approaches aimed at immunomodulation in the future. Keywords: community-acquired pneumonia, children under 1 year of age, interleukin-10 (IL-10), TNF-α, pro-inflammatory cytokines, childhood immunity, severe respiratory infections.

Keywords: community-acquired pneumonia, children under 1 year of age, interleukin-10 (IL-10), TNF-α, pro-inflammatory cytokines, childhood immunity, severe respiratory infections.

First page

418

Last page

422

For citation:Kuziyev D.V. - IMMUNOLOGICHESKAYA ROL' IL-10 I FNO-a PRI OSLOZHNENNOM VNEBOL'NICHNOM TONIZE U DETEY DO 1 GODA//New Day in Medicine 10(84)2025 418-422 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

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