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  • 51 -2 (40) 2022 — Shokirov Kh.Sh., Kamalov T.T. — BIOCHEMICAL CHARACTERISTICS OF PATIENTS WITH SEVERE COMPLICATIONS OF THE DIABETIC FOOT SYNDROME (ULCER, GANGRENE, AMPUTION) ASSOCIATED WITH CHRONIC KIDNEY DISEASE

51 -2 (40) 2022 — Shokirov Kh.Sh., Kamalov T.T. — BIOCHEMICAL CHARACTERISTICS OF PATIENTS WITH SEVERE COMPLICATIONS OF THE DIABETIC FOOT SYNDROME (ULCER, GANGRENE, AMPUTION) ASSOCIATED WITH CHRONIC KIDNEY DISEASE

BIOCHEMICAL CHARACTERISTICS OF PATIENTS WITH SEVERE COMPLICATIONS OF THE DIABETIC FOOT SYNDROME (ULCER, GANGRENE, AMPUTION) ASSOCIATED WITH CHRONIC KIDNEY DISEASE

Shokirov Kh.Sh., Republican Specialized Scientific and Practical Medical Center of Endocrinology of the Ministry of Health of the Republic of Uzbekistan named after acad. Y.H. Turakulova, Uzbekistan

Kamalov T.T. Republican Specialized Scientific and Practical Medical Center of Endocrinology of the Ministry of Health of the Republic of Uzbekistan named after acad. Y.H. Turakulova, Uzbekistan

Resume

The purpose of the study: to study the biochemical characteristics of patients with severe complications of diabetic foot syndrome –DFS- (ulcer, gangrene, amputation) are associated with chronic kidney disease.

Material and methods. . 91 patients were examined with SD 2 type with DFS with severe complications in the period of 20, 21-2024 in the RSSPMCs of endocrinology, in the department of the diabetic foot. All observed patients were divided into 4 groups:

1 gr. – 25 patients with DFS, complicated by ulcers, gangrene and amputation and in combination with CKD (chronic kidney disease) 4-5 stages on hemodialysis

2 gr. – 25 patients with DFS, complicated by ulcers, gangrene and amputation in combination with CKD 4-5 stages without hemodialysis

3 gr – 20 patients with DFS, complicated by gangrene and amputation without CKD.

4 gr – 21 patients with   DFS, without severe complications, with the initial stage of CKD.

The control group amounted to 20 healthy persons.

Research methods – biochemical (bilirubin, straight, indirect, lipid spectrum, Alt, Ast, Coagulogram, blood sugar, glycated hemoglobin, urea, creatinine, SCF, wound pathogens, prokalcitonin, interleukin -6, Endothelium growth factor Veszov vegf-a and instrumental: ECG, MRI  of foot, Dopplerography of the main vessels of the legs, ultrasound of the internal organs, the eye bottom.

Research results. The highest indicators of the glycemia were observed in patients of 2 groups, that is, with DFS and CKD 4-5 st without hemodialysis. In this group of patients, the patients were also observed with reliably lower hemoglobin values (p <0.001), the glycated hemoglobin reliably higher values of urea, creatinine and SKF (p <0.001). In all patients, there were reliably reduced values of the higher density lipids (p <0.001) and the total Cholesterol (p <0.05).

Conclusions. The biochemical indicators were significantly violated in patients of 1 groups, that is, with DFS and CKD 4-5 st on hemodialysis, which indicates the need for further research in this group of patients.

Key words: diabetes mellitus 2 type, diabetic foot syndrome, chronic renal failure, hemodialysisСведения об авторах

First page

270

Last page

277

For citation: Shokirov Kh.Sh., Kamalov T.T. BIOCHEMICAL CHARACTERISTICS OF PATIENTS WITH SEVERE COMPLICATIONS OF THE DIABETIC FOOT SYNDROME (ULCER, GANGRENE, AMPUTION) ASSOCIATED WITH CHRONIC KIDNEY DISEASE //New Day in Medicine 2(40)2022 270-277 https://cutt.ly/5AFiaU0

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