69 -12 (86) 2025 - Muxtarova X.K. - CLINICAL AND BIOLOGICAL BASIS OF DEPRESSION

CLINICAL AND BIOLOGICAL BASIS OF DEPRESSION

Muxtarova X.K. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This article reviews the clinical manifestations and biological foundations of depression, focusing on its pathophysiology and neurobiological mechanisms. Key biological contributors—including neurotransmitter imbalance, neuroendocrine dysregulation, neuroinflammation, genetic vulnerability, and impaired neuroplasticity—are discussed. Clinical subtypes such as unipolar depression, melancholic depression, atypical depression, psychotic and somatic forms are reviewed. Diagnostic considerations and the clinical significance of depressive disorders are highlighted.

Key words: depression, serotonin, norepinephrine, HPA axis, neuroplasticity, melancholic depression, atypical depression.

First page

386

Last page

388

For citation:Muxtarova X.K. - CLINICAL AND BIOLOGICAL BASIS OF DEPRESSION//New Day in Medicine 12(86)2025 386-388 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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